Serine-linked PARP1 auto-modification controls PARP inhibitor response.

Serine-linked PARP1 auto-modification controls PARP inhibitor response.

Poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 are recruited and activated by DNA damage, resulting in ADP-ribosylation at numerous sites, both within PARP1 itself and in other proteins. Several PARP1 and PARP2 inhibitors are currently employed in the clinic or undergoing trials for treatment of va...

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Hlavní autoři: Prokhorova, E, Zobel, F, Smith, R, Zentout, S, Gibbs-Seymour, I, Schützenhofer, K, Peters, A, Groslambert, J, Zorzini, V, Agnew, T, Brognard, J, Nielsen, ML, Ahel, D, Huet, S, Suskiewicz, MJ, Ahel, I
Médium: Journal article
Jazyk:English
Vydáno: Springer Nature 2021

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