Advances in tenascin-C biology.
Tenascin-C is an extracellular matrix glycoprotein that is specifically and transiently expressed upon tissue injury. Upon tissue damage, tenascin-C plays a multitude of different roles that mediate both inflammatory and fibrotic processes to enable effective tissue repair. In the last decade, emerg...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1826280448873988096 |
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| author | Midwood, K Hussenet, T Langlois, B Orend, G |
| author_facet | Midwood, K Hussenet, T Langlois, B Orend, G |
| author_sort | Midwood, K |
| collection | OXFORD |
| description | Tenascin-C is an extracellular matrix glycoprotein that is specifically and transiently expressed upon tissue injury. Upon tissue damage, tenascin-C plays a multitude of different roles that mediate both inflammatory and fibrotic processes to enable effective tissue repair. In the last decade, emerging evidence has demonstrated a vital role for tenascin-C in cardiac and arterial injury, tumor angiogenesis and metastasis, as well as in modulating stem cell behavior. Here we highlight the molecular mechanisms by which tenascin-C mediates these effects and discuss the implications of mis-regulated tenascin-C expression in driving disease pathology. |
| first_indexed | 2024-03-07T00:13:52Z |
| format | Journal article |
| id | oxford-uuid:7a2af7bc-578e-4550-9fbf-5f1ee4724aa3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:13:52Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:7a2af7bc-578e-4550-9fbf-5f1ee4724aa32022-03-26T20:42:08ZAdvances in tenascin-C biology.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7a2af7bc-578e-4550-9fbf-5f1ee4724aa3EnglishSymplectic Elements at Oxford2011Midwood, KHussenet, TLanglois, BOrend, GTenascin-C is an extracellular matrix glycoprotein that is specifically and transiently expressed upon tissue injury. Upon tissue damage, tenascin-C plays a multitude of different roles that mediate both inflammatory and fibrotic processes to enable effective tissue repair. In the last decade, emerging evidence has demonstrated a vital role for tenascin-C in cardiac and arterial injury, tumor angiogenesis and metastasis, as well as in modulating stem cell behavior. Here we highlight the molecular mechanisms by which tenascin-C mediates these effects and discuss the implications of mis-regulated tenascin-C expression in driving disease pathology. |
| spellingShingle | Midwood, K Hussenet, T Langlois, B Orend, G Advances in tenascin-C biology. |
| title | Advances in tenascin-C biology. |
| title_full | Advances in tenascin-C biology. |
| title_fullStr | Advances in tenascin-C biology. |
| title_full_unstemmed | Advances in tenascin-C biology. |
| title_short | Advances in tenascin-C biology. |
| title_sort | advances in tenascin c biology |
| work_keys_str_mv | AT midwoodk advancesintenascincbiology AT hussenett advancesintenascincbiology AT langloisb advancesintenascincbiology AT orendg advancesintenascincbiology |