Exposing the exposures responsible for type 2 diabetes and obesity
The rising prevalences of type 2 diabetes and obesity constitute major threats to human health globally. Powerful social and economic factors influence the distribution of these diseases among and within populations. These factors act on a substrate of individual predisposition derived from the comp...
| Main Authors: | , |
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| Format: | Journal article |
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American Association for the Advancement of Science
2016
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| _version_ | 1797077160682323968 |
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| author | Franks, P McCarthy, M |
| author_facet | Franks, P McCarthy, M |
| author_sort | Franks, P |
| collection | OXFORD |
| description | The rising prevalences of type 2 diabetes and obesity constitute major threats to human health globally. Powerful social and economic factors influence the distribution of these diseases among and within populations. These factors act on a substrate of individual predisposition derived from the composite effects of inherited DNA variation and a range of environmental exposures experienced throughout the life course. Although “Western” lifestyle represents a convenient catch-all culprit for such exposures, effective treatment and prevention will be informed by characterization of the most critical, causal environmental factors. In this Review, we examine how burgeoning understanding of the genetic basis of type 2 diabetes and obesity can highlight nongenetic exposures that drive development of these conditions. |
| first_indexed | 2024-03-07T00:13:53Z |
| format | Journal article |
| id | oxford-uuid:7a2cdfc1-3c56-4ffb-91a4-2df62394712b |
| institution | University of Oxford |
| last_indexed | 2024-03-07T00:13:53Z |
| publishDate | 2016 |
| publisher | American Association for the Advancement of Science |
| record_format | dspace |
| spelling | oxford-uuid:7a2cdfc1-3c56-4ffb-91a4-2df62394712b2022-03-26T20:42:12ZExposing the exposures responsible for type 2 diabetes and obesityJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7a2cdfc1-3c56-4ffb-91a4-2df62394712bSymplectic Elements at OxfordAmerican Association for the Advancement of Science2016Franks, PMcCarthy, MThe rising prevalences of type 2 diabetes and obesity constitute major threats to human health globally. Powerful social and economic factors influence the distribution of these diseases among and within populations. These factors act on a substrate of individual predisposition derived from the composite effects of inherited DNA variation and a range of environmental exposures experienced throughout the life course. Although “Western” lifestyle represents a convenient catch-all culprit for such exposures, effective treatment and prevention will be informed by characterization of the most critical, causal environmental factors. In this Review, we examine how burgeoning understanding of the genetic basis of type 2 diabetes and obesity can highlight nongenetic exposures that drive development of these conditions. |
| spellingShingle | Franks, P McCarthy, M Exposing the exposures responsible for type 2 diabetes and obesity |
| title | Exposing the exposures responsible for type 2 diabetes and obesity |
| title_full | Exposing the exposures responsible for type 2 diabetes and obesity |
| title_fullStr | Exposing the exposures responsible for type 2 diabetes and obesity |
| title_full_unstemmed | Exposing the exposures responsible for type 2 diabetes and obesity |
| title_short | Exposing the exposures responsible for type 2 diabetes and obesity |
| title_sort | exposing the exposures responsible for type 2 diabetes and obesity |
| work_keys_str_mv | AT franksp exposingtheexposuresresponsiblefortype2diabetesandobesity AT mccarthym exposingtheexposuresresponsiblefortype2diabetesandobesity |