Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity.

OBJECTIVE: The precise molecular mechanisms contributing to the development of insulin resistance, impaired glucose tolerance (IGT), and type 2 diabetes are largely unknown. Altered endogenous glucocorticoid metabolism, including 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which gener...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Tomlinson, J, Finney, J, Gay, C, Hughes, B, Hughes, S, Stewart, P
Fformat: Journal article
Iaith:English
Cyhoeddwyd: 2008