Symptomatic, radiological and pathological involvement of the hypothalamus in neuromyelitis optica.
This study describes a young girl who presented with involuntary weight loss, spontaneous vomiting and behavioural change. Imaging confirmed hypothalamic and brainstem involvement. Routine investigations (including cerebrospinal fluid analysis and neuromyelitis optica IgG) were unhelpful. Biopsy of...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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| _version_ | 1826280473411715072 |
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| author | Viegas, S Weir, A Esiri, M Kuker, W Waters, P Leite, M Vincent, A Palace, J |
| author_facet | Viegas, S Weir, A Esiri, M Kuker, W Waters, P Leite, M Vincent, A Palace, J |
| author_sort | Viegas, S |
| collection | OXFORD |
| description | This study describes a young girl who presented with involuntary weight loss, spontaneous vomiting and behavioural change. Imaging confirmed hypothalamic and brainstem involvement. Routine investigations (including cerebrospinal fluid analysis and neuromyelitis optica IgG) were unhelpful. Biopsy of the hypothalamic lesion implicated an aggressive inflammatory aetiology. There was a response to conventional immunosuppression, while a further relapse responded to plasma exchange. She died 21 months after presentation. Postmortem examination was highly suggestive of neuromyelitis optica, which was subsequently confirmed following the identification of aquaporin 4 antibodies. |
| first_indexed | 2024-03-07T00:14:14Z |
| format | Journal article |
| id | oxford-uuid:7a45e117-0ea0-4f77-bb7f-6183466c9672 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:14:14Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:7a45e117-0ea0-4f77-bb7f-6183466c96722022-03-26T20:42:58ZSymptomatic, radiological and pathological involvement of the hypothalamus in neuromyelitis optica.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7a45e117-0ea0-4f77-bb7f-6183466c9672EnglishSymplectic Elements at Oxford2009Viegas, SWeir, AEsiri, MKuker, WWaters, PLeite, MVincent, APalace, JThis study describes a young girl who presented with involuntary weight loss, spontaneous vomiting and behavioural change. Imaging confirmed hypothalamic and brainstem involvement. Routine investigations (including cerebrospinal fluid analysis and neuromyelitis optica IgG) were unhelpful. Biopsy of the hypothalamic lesion implicated an aggressive inflammatory aetiology. There was a response to conventional immunosuppression, while a further relapse responded to plasma exchange. She died 21 months after presentation. Postmortem examination was highly suggestive of neuromyelitis optica, which was subsequently confirmed following the identification of aquaporin 4 antibodies. |
| spellingShingle | Viegas, S Weir, A Esiri, M Kuker, W Waters, P Leite, M Vincent, A Palace, J Symptomatic, radiological and pathological involvement of the hypothalamus in neuromyelitis optica. |
| title | Symptomatic, radiological and pathological involvement of the hypothalamus in neuromyelitis optica. |
| title_full | Symptomatic, radiological and pathological involvement of the hypothalamus in neuromyelitis optica. |
| title_fullStr | Symptomatic, radiological and pathological involvement of the hypothalamus in neuromyelitis optica. |
| title_full_unstemmed | Symptomatic, radiological and pathological involvement of the hypothalamus in neuromyelitis optica. |
| title_short | Symptomatic, radiological and pathological involvement of the hypothalamus in neuromyelitis optica. |
| title_sort | symptomatic radiological and pathological involvement of the hypothalamus in neuromyelitis optica |
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