BRD3 and BRD4 BET bromodomain proteins differentially regulate skeletal myogenesis

BRD3 and BRD4 BET bromodomain proteins differentially regulate skeletal myogenesis

Myogenic differentiation proceeds through a highly coordinated cascade of gene activation that necessitates epigenomic changes in chromatin structure. Using a screen of small molecule epigenetic probes we identified three compounds which inhibited myogenic differentiation in C2C12 myoblasts; (+)-JQ1...

Podrobná bibliografie
Hlavní autoři:	Roberts, T, Etxaniz, U, Dall'Agnese, A, Wu, S, Chiang, C, Brennan, P, Wood, M, Puri, P
Médium:	Journal article
Jazyk:	English
Vydáno:	Springer Nature 2017

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