BRD3 and BRD4 BET bromodomain proteins differentially regulate skeletal myogenesis

BRD3 and BRD4 BET bromodomain proteins differentially regulate skeletal myogenesis

Myogenic differentiation proceeds through a highly coordinated cascade of gene activation that necessitates epigenomic changes in chromatin structure. Using a screen of small molecule epigenetic probes we identified three compounds which inhibited myogenic differentiation in C2C12 myoblasts; (+)-JQ1...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Roberts, T, Etxaniz, U, Dall'Agnese, A, Wu, S, Chiang, C, Brennan, P, Wood, M, Puri, P
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	Springer Nature 2017

Παρόμοια τεκμήρια

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ανά: Clark, P, κ.ά.
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ανά: Jude T Deeney, κ.ά.
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ανά: Adam P. Cribbs, κ.ά.
Έκδοση: (2021-02-01)

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ανά: Jennings, L, κ.ά.
Έκδοση: (2018)

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ανά: Naidi Yang, κ.ά.
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ανά: Martin Hügle, κ.ά.
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ανά: Abhiraami Kannan-Sundhari, κ.ά.
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ανά: Nagarajan, S, κ.ά.
Έκδοση: (2014)

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ανά: Nagarajan, S, κ.ά.
Έκδοση: (2014)

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ανά: Kramm, A, κ.ά.
Έκδοση: (2013)

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ανά: Floyd, Scott R., κ.ά.
Έκδοση: (2014)

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ανά: Segatto, M, κ.ά.
Έκδοση: (2017)

tBRD-1 selectively controls gene activity in the Drosophila testis and interacts with two new members of the bromodomain and extra-terminal (BET) family.
ανά: Ina Theofel, κ.ά.
Έκδοση: (2014-01-01)

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ανά: Sankari Nagarajan, κ.ά.
Έκδοση: (2014-07-01)

tBRD-1 and tBRD-2 regulate expression of genes necessary for spermatid differentiation
ανά: Ina Theofel, κ.ά.
Έκδοση: (2017-04-01)

Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival
ανά: Marco Segatto, κ.ά.
Έκδοση: (2017-11-01)

Dicer promotes genome stability via the bromodomain transcriptional co-activator BRD4
ανά: M. J. Gutbrod, κ.ά.
Έκδοση: (2022-02-01)

9H-purine scaffold reveals induced-fit pocket plasticity of the BRD9 bromodomain
ανά: Picaud, S, κ.ά.
Έκδοση: (2015)

Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis
ανά: Ji-Eun Lee, κ.ά.
Έκδοση: (2017-12-01)

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ανά: Katja Leser, κ.ά.
Έκδοση: (2012-05-01)

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ανά: Minghua Yang, κ.ά.
Έκδοση: (2022-10-01)

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ανά: Francesca Malvezzi, κ.ά.
Έκδοση: (2021-11-01)

Inhibition of BRD4 Bromodomains Is a Potent Novel Strategy to Target Apoptosis Resistance in Paediatric ALL
ανά: Da Costa, D, κ.ά.
Έκδοση: (2011)

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ανά: C. Otto, κ.ά.
Έκδοση: (2019-11-01)

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ανά: Jack Calder, κ.ά.
Έκδοση: (2021-03-01)

The BET Family Member BRD4 Interacts with OCT4 and Regulates Pluripotency Gene Expression
ανά: Tao Wu, κ.ά.
Έκδοση: (2015-03-01)

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ανά: Joshua A. Nord, κ.ά.
Έκδοση: (2022-09-01)

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ανά: Silvia Consalvi, κ.ά.
Έκδοση: (2017-01-01)

Bromodomain protein Brd4 plays a key role in Merkel cell polyomavirus DNA replication.
ανά: Xin Wang, κ.ά.
Έκδοση: (2012-01-01)

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ανά: Tiyun Wu, κ.ά.
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Analysis of the papillomavirus E2 and bromodomain protein Brd4 interaction using bimolecular fluorescence complementation.
ανά: Christine M Helfer, κ.ά.
Έκδοση: (2013-01-01)

Inducible In Vivo Silencing of Brd4 Identifies Potential Toxicities of Sustained BET Protein Inhibition
ανά: Jessica E. Bolden, κ.ά.
Έκδοση: (2014-09-01)

Developing chemical probes for the BET bromodomains
ανά: Hewings, D, κ.ά.
Έκδοση: (2012)

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ανά: Shailesh Tripathi, κ.ά.
Έκδοση: (2016-01-01)

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ανά: Christine M. Helfer, κ.ά.
Έκδοση: (2014-08-01)

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ανά: Fernando D. Prieto-Martínez, κ.ά.
Έκδοση: (2018-07-01)

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ανά: Yi Liu, κ.ά.
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