BRD3 and BRD4 BET bromodomain proteins differentially regulate skeletal myogenesis

BRD3 and BRD4 BET bromodomain proteins differentially regulate skeletal myogenesis

Myogenic differentiation proceeds through a highly coordinated cascade of gene activation that necessitates epigenomic changes in chromatin structure. Using a screen of small molecule epigenetic probes we identified three compounds which inhibited myogenic differentiation in C2C12 myoblasts; (+)-JQ1...

Full beskrivning

Bibliografiska uppgifter
Huvudupphovsmän:	Roberts, T, Etxaniz, U, Dall'Agnese, A, Wu, S, Chiang, C, Brennan, P, Wood, M, Puri, P
Materialtyp:	Journal article
Språk:	English
Publicerad:	Springer Nature 2017

Liknande verk

BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis
av: Thomas C. Roberts, et al.
Publicerad: (2017-07-01)

Development of chemical probes for the bromodomains of BRD7 and BRD9
av: Clark, P, et al.
Publicerad: (2016)

Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function
av: Cribbs, AP, et al.
Publicerad: (2021)

BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell.
av: Jude T Deeney, et al.
Publicerad: (2016-01-01)

Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function
av: Adam P. Cribbs, et al.
Publicerad: (2021-02-01)

BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability
av: Jennings, L, et al.
Publicerad: (2018)

An interplay between BRD4 and G9a regulates skeletal myogenesis
av: Naidi Yang, et al.
Publicerad: (2022-09-01)

Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes
av: Martin Hügle, et al.
Publicerad: (2016-06-01)

Bromodomain Protein BRD4 Is Essential for Hair Cell Function and Survival
av: Abhiraami Kannan-Sundhari, et al.
Publicerad: (2020-09-01)

Bromodomain protein BRD4 is required for estrogen receptor-dependent enhancer activation and gene transcription.
av: Nagarajan, S, et al.
Publicerad: (2014)

Bromodomain Protein BRD4 Is Required for Estrogen Receptor-Dependent Enhancer Activation and Gene Transcription
av: Nagarajan, S, et al.
Publicerad: (2014)

An epigenetic screen identifies bromodomain-containing protein 4 (BRD4) as a critical component for osteoblast differentiation
av: Kramm, A, et al.
Publicerad: (2013)

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling
av: Floyd, Scott R., et al.
Publicerad: (2014)

Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival
av: Segatto, M, et al.
Publicerad: (2017)

tBRD-1 selectively controls gene activity in the Drosophila testis and interacts with two new members of the bromodomain and extra-terminal (BET) family.
av: Ina Theofel, et al.
Publicerad: (2014-01-01)

Bromodomain Protein BRD4 Is Required for Estrogen Receptor-Dependent Enhancer Activation and Gene Transcription
av: Sankari Nagarajan, et al.
Publicerad: (2014-07-01)

tBRD-1 and tBRD-2 regulate expression of genes necessary for spermatid differentiation
av: Ina Theofel, et al.
Publicerad: (2017-04-01)

Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival
av: Marco Segatto, et al.
Publicerad: (2017-11-01)

Dicer promotes genome stability via the bromodomain transcriptional co-activator BRD4
av: M. J. Gutbrod, et al.
Publicerad: (2022-02-01)

9H-purine scaffold reveals induced-fit pocket plasticity of the BRD9 bromodomain
av: Picaud, S, et al.
Publicerad: (2015)

Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis
av: Ji-Eun Lee, et al.
Publicerad: (2017-12-01)

The bromodomain-containing protein tBRD-1 is specifically expressed in spermatocytes and is essential for male fertility
av: Katja Leser, et al.
Publicerad: (2012-05-01)

Bromodomain-containing protein 4 (BRD4) as an epigenetic regulator of fatty acid metabolism genes and ferroptosis
av: Minghua Yang, et al.
Publicerad: (2022-10-01)

Phosphorylation-dependent BRD4 dimerization and implications for therapeutic inhibition of BET family proteins
av: Francesca Malvezzi, et al.
Publicerad: (2021-11-01)

Inhibition of BRD4 Bromodomains Is a Potent Novel Strategy to Target Apoptosis Resistance in Paediatric ALL
av: Da Costa, D, et al.
Publicerad: (2011)

Targeting bromodomain-containing protein 4 (BRD4) inhibits MYC expression in colorectal cancer cells
av: C. Otto, et al.
Publicerad: (2019-11-01)

Resistance to BET inhibitors in lung adenocarcinoma is mediated by casein kinase phosphorylation of BRD4
av: Jack Calder, et al.
Publicerad: (2021-03-01)

The BET Family Member BRD4 Interacts with OCT4 and Regulates Pluripotency Gene Expression
av: Tao Wu, et al.
Publicerad: (2015-03-01)

N-terminal BET bromodomain inhibitors disrupt a BRD4-p65 interaction and reduce inducible nitric oxide synthase transcription in pancreatic β-cells
av: Joshua A. Nord, et al.
Publicerad: (2022-09-01)

Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation
av: Silvia Consalvi, et al.
Publicerad: (2017-01-01)

Bromodomain protein Brd4 plays a key role in Merkel cell polyomavirus DNA replication.
av: Xin Wang, et al.
Publicerad: (2012-01-01)

Bromodomain protein BRD4 directs mitotic cell division of mouse fibroblasts by inhibiting DNA damage
av: Tiyun Wu, et al.
Publicerad: (2024-07-01)

Analysis of the papillomavirus E2 and bromodomain protein Brd4 interaction using bimolecular fluorescence complementation.
av: Christine M Helfer, et al.
Publicerad: (2013-01-01)

Inducible In Vivo Silencing of Brd4 Identifies Potential Toxicities of Sustained BET Protein Inhibition
av: Jessica E. Bolden, et al.
Publicerad: (2014-09-01)

Developing chemical probes for the BET bromodomains
av: Hewings, D, et al.
Publicerad: (2012)

A Novel Phenanthridionone Based Scaffold As a Potential Inhibitor of the BRD2 Bromodomain: Crystal Structure of the Complex.
av: Shailesh Tripathi, et al.
Publicerad: (2016-01-01)

The Cellular Bromodomain Protein Brd4 has Multiple Functions in E2-Mediated Papillomavirus Transcription Activation
av: Christine M. Helfer, et al.
Publicerad: (2014-08-01)

Flavonoids as Putative Epi-Modulators: Insight into Their Binding Mode with BRD4 Bromodomains Using Molecular Docking and Dynamics
av: Fernando D. Prieto-Martínez, et al.
Publicerad: (2018-07-01)

Methylation of BRD4 by PRMT1 regulates BRD4 phosphorylation and promotes ovarian cancer invasion
av: Yi Liu, et al.
Publicerad: (2023-09-01)

Retinoblastoma protein as an intrinsic BRD4 inhibitor modulates small molecule BET inhibitor sensitivity in cancer
av: Donglin Ding, et al.
Publicerad: (2022-10-01)