Recruitment of parvalbumin-positive interneurons determines hippocampal function and associated behavior.
Perisomatic inhibition provided by a subgroup of GABAergic interneurons plays a critical role in timing the output of pyramidal cells. To test their contribution at the network and the behavioral level, we generated genetically modified mice in which the excitatory drive was selectively reduced eith...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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| _version_ | 1826280496848437248 |
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| author | Fuchs, E Zivkovic, A Cunningham, M Middleton, S Lebeau, F Bannerman, D Rozov, A Whittington, M Traub, R Rawlins, J Monyer, H |
| author_facet | Fuchs, E Zivkovic, A Cunningham, M Middleton, S Lebeau, F Bannerman, D Rozov, A Whittington, M Traub, R Rawlins, J Monyer, H |
| author_sort | Fuchs, E |
| collection | OXFORD |
| description | Perisomatic inhibition provided by a subgroup of GABAergic interneurons plays a critical role in timing the output of pyramidal cells. To test their contribution at the network and the behavioral level, we generated genetically modified mice in which the excitatory drive was selectively reduced either by the knockout of the GluR-D or by conditional ablation of the GluR-A subunit in parvalbumin-positive cells. Comparable cell type-specific reductions of AMPA-mediated currents were obtained. Kainate-induced gamma oscillations exhibited reduced power in hippocampal slices from GluR-D-/- and GluR-A(PVCre-/-) mice. Experimental and modeling data indicated that this alteration could be accounted for by imprecise spike timing of fast-spiking cells (FS) caused by smaller interneuronal EPSPs. GluR-D-/- and GluR-A(PVCre-/-) mice exhibited similar impairments in hippocampus-dependent tasks. These findings directly show the effects of insufficient recruitment of fast-spiking cells at the network and behavioral level and demonstrate the role of this subpopulation for working and episodic-like memory. |
| first_indexed | 2024-03-07T00:14:35Z |
| format | Journal article |
| id | oxford-uuid:7a61fac9-475c-4b12-a2b1-8b1d1ce3c61d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:14:35Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:7a61fac9-475c-4b12-a2b1-8b1d1ce3c61d2022-03-26T20:43:44ZRecruitment of parvalbumin-positive interneurons determines hippocampal function and associated behavior.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7a61fac9-475c-4b12-a2b1-8b1d1ce3c61dEnglishSymplectic Elements at Oxford2007Fuchs, EZivkovic, ACunningham, MMiddleton, SLebeau, FBannerman, DRozov, AWhittington, MTraub, RRawlins, JMonyer, HPerisomatic inhibition provided by a subgroup of GABAergic interneurons plays a critical role in timing the output of pyramidal cells. To test their contribution at the network and the behavioral level, we generated genetically modified mice in which the excitatory drive was selectively reduced either by the knockout of the GluR-D or by conditional ablation of the GluR-A subunit in parvalbumin-positive cells. Comparable cell type-specific reductions of AMPA-mediated currents were obtained. Kainate-induced gamma oscillations exhibited reduced power in hippocampal slices from GluR-D-/- and GluR-A(PVCre-/-) mice. Experimental and modeling data indicated that this alteration could be accounted for by imprecise spike timing of fast-spiking cells (FS) caused by smaller interneuronal EPSPs. GluR-D-/- and GluR-A(PVCre-/-) mice exhibited similar impairments in hippocampus-dependent tasks. These findings directly show the effects of insufficient recruitment of fast-spiking cells at the network and behavioral level and demonstrate the role of this subpopulation for working and episodic-like memory. |
| spellingShingle | Fuchs, E Zivkovic, A Cunningham, M Middleton, S Lebeau, F Bannerman, D Rozov, A Whittington, M Traub, R Rawlins, J Monyer, H Recruitment of parvalbumin-positive interneurons determines hippocampal function and associated behavior. |
| title | Recruitment of parvalbumin-positive interneurons determines hippocampal function and associated behavior. |
| title_full | Recruitment of parvalbumin-positive interneurons determines hippocampal function and associated behavior. |
| title_fullStr | Recruitment of parvalbumin-positive interneurons determines hippocampal function and associated behavior. |
| title_full_unstemmed | Recruitment of parvalbumin-positive interneurons determines hippocampal function and associated behavior. |
| title_short | Recruitment of parvalbumin-positive interneurons determines hippocampal function and associated behavior. |
| title_sort | recruitment of parvalbumin positive interneurons determines hippocampal function and associated behavior |
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