Noradrenergic modulation of space exploration in visual neglect.
Visual neglect after stroke is often associated with a failure to explore contralesional space. Here, we show that guanfacine, a noradrenergic agonist that modulates dorsolateral prefrontal cortex, improves leftward space exploration in selected right-hemisphere patients with neglect. The positive e...
| Egile Nagusiak: | , , , |
|---|---|
| Formatua: | Journal article |
| Hizkuntza: | English |
| Argitaratua: |
2006
|
| _version_ | 1826280508763406336 |
|---|---|
| author | Malhotra, P Parton, A Greenwood, R Husain, M |
| author_facet | Malhotra, P Parton, A Greenwood, R Husain, M |
| author_sort | Malhotra, P |
| collection | OXFORD |
| description | Visual neglect after stroke is often associated with a failure to explore contralesional space. Here, we show that guanfacine, a noradrenergic agonist that modulates dorsolateral prefrontal cortex, improves leftward space exploration in selected right-hemisphere patients with neglect. The positive effects of guanfacine were associated with extended ability to maintain attention on task. The results suggest that neuropharmacological targeting of intact frontal areas might be one way to enhance cognitive function after damage to posterior brain regions in selected individuals. |
| first_indexed | 2024-03-07T00:14:46Z |
| format | Journal article |
| id | oxford-uuid:7a6d5e21-7bf1-4add-a941-6e5a00faba91 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:14:46Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:7a6d5e21-7bf1-4add-a941-6e5a00faba912022-03-26T20:44:06ZNoradrenergic modulation of space exploration in visual neglect.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7a6d5e21-7bf1-4add-a941-6e5a00faba91EnglishSymplectic Elements at Oxford2006Malhotra, PParton, AGreenwood, RHusain, MVisual neglect after stroke is often associated with a failure to explore contralesional space. Here, we show that guanfacine, a noradrenergic agonist that modulates dorsolateral prefrontal cortex, improves leftward space exploration in selected right-hemisphere patients with neglect. The positive effects of guanfacine were associated with extended ability to maintain attention on task. The results suggest that neuropharmacological targeting of intact frontal areas might be one way to enhance cognitive function after damage to posterior brain regions in selected individuals. |
| spellingShingle | Malhotra, P Parton, A Greenwood, R Husain, M Noradrenergic modulation of space exploration in visual neglect. |
| title | Noradrenergic modulation of space exploration in visual neglect. |
| title_full | Noradrenergic modulation of space exploration in visual neglect. |
| title_fullStr | Noradrenergic modulation of space exploration in visual neglect. |
| title_full_unstemmed | Noradrenergic modulation of space exploration in visual neglect. |
| title_short | Noradrenergic modulation of space exploration in visual neglect. |
| title_sort | noradrenergic modulation of space exploration in visual neglect |
| work_keys_str_mv | AT malhotrap noradrenergicmodulationofspaceexplorationinvisualneglect AT partona noradrenergicmodulationofspaceexplorationinvisualneglect AT greenwoodr noradrenergicmodulationofspaceexplorationinvisualneglect AT husainm noradrenergicmodulationofspaceexplorationinvisualneglect |