Computational analysis of binding between malarial dihydrofolate reductases and anti-folates

Computational analysis of binding between malarial dihydrofolate reductases and anti-folates

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Background: <em>Plasmodium falciparum</em> readily develops resistance to the anti-folates pyrimethamine and proguanil via a characteristic set of mutations in the dihydrofolate reductase (PfDHFR) gene that leads to reduced competitive drug binding at the enzyme's active site. Analo...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Choowongkomon, K, Theppabutr, S, Songtawee, N, Day, N, White, N, Woodrow, C, Imwong, M
التنسيق: Journal article
اللغة:English
منشور في: BioMed Central 2010
الموضوعات:
Malaria
Tropical medicine
Biochemistry
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