Computational analysis of binding between malarial dihydrofolate reductases and anti-folates
Background: <em>Plasmodium falciparum</em> readily develops resistance to the anti-folates pyrimethamine and proguanil via a characteristic set of mutations in the dihydrofolate reductase (PfDHFR) gene that leads to reduced competitive drug binding at the enzyme's active site. Analo...
| Glavni autori: | , , , , , , |
|---|---|
| Format: | Journal article |
| Jezik: | English |
| Izdano: |
BioMed Central
2010
|
| Teme: |