Computational analysis of binding between malarial dihydrofolate reductases and anti-folates
Background: <em>Plasmodium falciparum</em> readily develops resistance to the anti-folates pyrimethamine and proguanil via a characteristic set of mutations in the dihydrofolate reductase (PfDHFR) gene that leads to reduced competitive drug binding at the enzyme's active site. Analo...
| Main Authors: | , , , , , , |
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| 格式: | Journal article |
| 語言: | English |
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BioMed Central
2010
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| 主題: |