The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.

The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.

The cellular response to hypoxia includes the hypoxia-inducible factor-1 (HIF-1)-induced transcription of genes involved in diverse processes such as glycolysis and angiogenesis. Induction of the HIF-regulated genes, as a consequence of the microenvironment or genetic changes, is known to have an im...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Talks, K, Turley, H, Gatter, K, Maxwell, P, Pugh, C, Ratcliffe, P, Harris, A
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2000

Eitemau Tebyg

Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer.
gan: Leek, R, et al.
Cyhoeddwyd: (2002)

Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1alpha). Characterization of hif-1alpha-dependent and -independent hypoxia-inducible gene expression.
gan: Wood, S, et al.
Cyhoeddwyd: (1998)

Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia.
gan: Sowter, H, et al.
Cyhoeddwyd: (2003)

Expression of angiogenic factors and hypoxia inducible factors HIF 1, HIF 2 and CA IX in non-Hodgkin's lymphoma.
gan: Stewart, M, et al.
Cyhoeddwyd: (2002)

Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha.
gan: Elkins, J, et al.
Cyhoeddwyd: (2003)

Hypoxia-inducible factor (HIF1A and HIF2A), angiogenesis, and chemoradiotherapy outcome of squamous cell head-and-neck cancer.
gan: Koukourakis, M, et al.
Cyhoeddwyd: (2002)

Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcripts.
gan: Mole, D, et al.
Cyhoeddwyd: (2009)

Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha.
gan: Wiesener, MS, et al.
Cyhoeddwyd: (1998)

Effects of HIF-1alpha and HIF2alpha on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts.
gan: Biswas, S, et al.
Cyhoeddwyd: (2010)

Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs.
gan: Wiesener, MS, et al.
Cyhoeddwyd: (2003)

Expression of BNIP3 correlates with hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha and the androgen receptor in prostate cancer and is regulated directly by hypoxia but not androgens in cell lines.
gan: Shaida, N, et al.
Cyhoeddwyd: (2008)

Targeting tumors through the HIF system.
gan: Ratcliffe, P, et al.
Cyhoeddwyd: (2000)

Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways.
gan: Elvidge, G, et al.
Cyhoeddwyd: (2006)

Regulation of angiogenesis by hypoxia: role of the HIF system.
gan: Pugh, C, et al.
Cyhoeddwyd: (2003)

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
gan: Hon, W, et al.
Cyhoeddwyd: (2002)

The number of regulatory T cells in prostate cancer is associated with the androgen receptor and hypoxia-inducible factor (HIF)-2alpha but not HIF-1alpha.
gan: Fox, S, et al.
Cyhoeddwyd: (2007)

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis.
gan: Carmeliet, P, et al.
Cyhoeddwyd: (1998)

HIF-1 and HIF-2: working alone or together in hypoxia?
gan: Ratcliffe, P
Cyhoeddwyd: (2007)

Tissue Expression of Hypoxia-Inducible Factor 1 Alpha (HIF-1A) in Wilms Tumor
gan: Emel Tekin, et al.
Cyhoeddwyd: (2019-03-01)

Distinct roles for the hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha in human osteoclast formation and function
gan: Knowles, H
Cyhoeddwyd: (2020)

Regulation of the Drosophila bHLH-PAS protein Sima by hypoxia: functional evidence for homology with mammalian HIF-1 alpha.
gan: Bacon, N, et al.
Cyhoeddwyd: (1998)

Synergistic inhibition of tumour cell proliferation and upregulation of Hif-1 alpha using two anti-transferrin receptor antibodies.
gan: Jones, D, et al.
Cyhoeddwyd: (2004)

Activation of the HIF pathway in cancer.
gan: Maxwell, P, et al.
Cyhoeddwyd: (2001)

Regulation of the HIF pathway: enzymatic hydroxylation of a conserved prolyl residue in hypoxia-inducible factor alpha subunits governs capture by the pVHL E3 ubiquitin ligase complex.
gan: Mole, D, et al.
Cyhoeddwyd: (2002)

Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing.
gan: Webb, J, et al.
Cyhoeddwyd: (2009)

Signalling hypoxia by HIF hydroxylases.
gan: Schofield, C, et al.
Cyhoeddwyd: (2005)

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.
gan: Raval, R, et al.
Cyhoeddwyd: (2005)

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.
gan: Pollard, P, et al.
Cyhoeddwyd: (2008)

HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia.
gan: Freya M Mowat, et al.
Cyhoeddwyd: (2010-06-01)

The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.
gan: Pugh, C, et al.
Cyhoeddwyd: (2003)

Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival.
gan: Giatromanolaki, A, et al.
Cyhoeddwyd: (2001)

C2028T polymorphism in exon 12 and dinucleotide repeat polymorphism in intron 13 of the HIF-1alpha gene define HIF-1alpha protein expression in non-small cell lung cancer.
gan: Koukourakis, M, et al.
Cyhoeddwyd: (2006)

The HIF pathway: implications for patterns of gene expression in cancer.
gan: Wykoff, C, et al.
Cyhoeddwyd: (2001)

Hypoxia inducible factor-1 alpha (Hif-1 alpha) polymorphism in lymphoma and reactive lymphoid hyperplasia
gan: SEMA YILMAZ, et al.
Cyhoeddwyd: (2019-08-01)

A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas.
gan: Dahia, P, et al.
Cyhoeddwyd: (2005)

Hypoxia and HIF pathway in cancer and the placenta
gan: Macklin, P, et al.
Cyhoeddwyd: (2017)

Hypoxia-induced cytotoxic drug resistance in osteosarcoma is independent of HIF-1Alpha.
gan: Jennifer Adamski, et al.
Cyhoeddwyd: (2013-01-01)

Severe Intermittent Hypoxia Modulates the Macrophage Phenotype and Impairs Wound Healing Through Downregulation of HIF-2α
gan: Chen L, et al.
Cyhoeddwyd: (2022-08-01)

Expression of HIF-1alpha, HIF-2alpha (EPAS1), and their target genes in paraganglioma and pheochromocytoma with VHL and SDH mutations.
gan: Pollard, P, et al.
Cyhoeddwyd: (2006)

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
gan: Jaakkola, P, et al.
Cyhoeddwyd: (2001)