Structural dynamics of the ubiquitin specific protease UPS30 in complex with a cyanopyrrolidine-containing covalent inhibitor

Structural dynamics of the ubiquitin specific protease UPS30 in complex with a cyanopyrrolidine-containing covalent inhibitor

Inhibition of the mitochondrial deubiquitinating enzyme USP30 is neuroprotective and presents therapeutic opportunities for the treatment of idiopathic Parkinson’s Disease and mitophagy-related disorders. We have integrated structural and quantitative proteomics with biochemical assays to decipher t...

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Bibliographic Details
Main Authors: O’Brien, DP, Jones, HBL, Shi, Y, Guenther, F, Vendrell, I, Viner, R, Brennan, PE, Mead, E, Zarganes-Tzitzikas, T, Davis, JB, Pinto-Fernández, A, England, KS, Murphy, EJ, Turnbull, AP, Kessler, BM
Format: Internet publication
Language:English
Published: 2024

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