Estimation of the in-vivo minimum inhibitory concentration of cipargamin in uncomplicated Plasmodium falciparum malaria

Estimation of the in-vivo minimum inhibitory concentration of cipargamin in uncomplicated Plasmodium falciparum malaria

The minimum inhibitory concentration (MIC) of an antimalarial drug for a particular infection is the drug level associated with a net parasite multiplication rate of one per asexual cycle. To ensure cure of malaria the MIC must be exceeded until all parasites have been eliminated. The development of...

Full description

Bibliographic Details
Main Authors:	Tinh Tran, H, White, N, Thanh Nguyen, T, Toa Nhu, H, Duc Phung, T, Tarning, J, Nosten, F, Magnusson, B, Prakash Jain, J, Hamed, K
Format:	Journal article
Published:	American Society for Microbiology 2016

Similar Items

Assessment in vitro of the antimalarial and transmission-blocking activities of cipargamin and ganaplacide in artemisinin-resistant Plasmodium falciparum
by: Yipsirimetee, A, et al.
Published: (2022)

Pharmacokinetics of piperaquine in pregnant women in Sudan with uncomplicated Plasmodium falciparum malaria.
by: Adam, I, et al.
Published: (2012)

Pharmacokinetics of piperaquine in pregnant women in Sudan with uncomplicated Plasmodium falciparum malaria
by: Adam, I, et al.
Published: (2012)

A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin
by: Deyun Qiu, et al.
Published: (2022-09-01)

Population pharmacokinetics of quinine in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda.
by: Kloprogge, F, et al.
Published: (2014)

Population Pharmacokinetics of Lumefantrine in Pregnant and Nonpregnant Women With Uncomplicated Plasmodium falciparum Malaria in Uganda.
by: Kloprogge, F, et al.
Published: (2013)

Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda.
by: Tarning, J, et al.
Published: (2012)

Pharmacokinetic properties of artemether, dihydroartemisinin, lumefantrine, and quinine in pregnant women with uncomplicated plasmodium falciparum malaria in Uganda.
by: Tarning, J, et al.
Published: (2013)

Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated <it>Plasmodium falciparum</it> malaria in Uganda
by: Tarning Joel, et al.
Published: (2012-08-01)

Hepatic safety and tolerability of cipargamin (KAE609), in adult patients with Plasmodium falciparum malaria: a randomized, phase II, controlled, dose-escalation trial in sub-Saharan Africa
by: Gilles Ndayisaba, et al.
Published: (2021-12-01)

Population pharmacokinetics of lumefantrine in pregnant women treated with artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria.
by: Tarning, J, et al.
Published: (2009)

Human Gene Expression in Uncomplicated Plasmodium falciparum Malaria
by: James M. Colborn, et al.
Published: (2015-01-01)

A population pharmacokinetic model of piperaquine in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum malaria in Sudan.
by: Hoglund, R, et al.
Published: (2012)

Clinically uncomplicated Plasmodium falciparum malaria with high schizontaemia: a case report.
by: Lwin, K, et al.
Published: (2008)

A population pharmacokinetic model of piperaquine in pregnant and non-pregnant women with uncomplicated <it>Plasmodium falciparum</it> malaria in Sudan
by: Hoglund Richard M, et al.
Published: (2012-11-01)

Clinically uncomplicated <it>Plasmodium falciparum </it>malaria with high schizontaemia: A case report
by: Ashley Elizabeth A, et al.
Published: (2008-04-01)

Pyronaridine-artesunate for uncomplicated falciparum malaria.
by: Nosten, F
Published: (2010)

Lumefantrine and desbutyl-lumefantrine population pharmacokinetic-pharmacodynamic relationships in pregnant women with uncomplicated Plasmodium falciparum malaria on the Thailand-Myanmar border
by: Kloprogge, F, et al.
Published: (2015)

Evaluation of atovaquone in the treatment of patients with uncomplicated Plasmodium falciparum malaria.
by: Chiodini, P, et al.
Published: (1995)

Efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Nepal
by: Prakash Ghimire, et al.
Published: (2018-08-01)

Population pharmacokinetics of artemether, dihydroartemisinin and lumefantrine in Rwandese pregnant women treated for uncomplicated Plasmodium falciparum malaria
by: Das, J, et al.
Published: (2018)

Population pharmacokinetics of amodiaquine and piperaquine in African pregnant women with uncomplicated Plasmodium falciparum infections
by: Junjie Ding, et al.
Published: (2024-11-01)

Fever in uncomplicated Plasmodium falciparum infection: effects of quinine and paracetamol.
by: Krishna, S, et al.
Published: (1995)

A distinct peripheral blood monocyte phenotype is associated with parasite inhibitory activity in acute uncomplicated Plasmodium falciparum malaria.
by: Pattamawan Chimma, et al.
Published: (2009-10-01)

Pharmacokinetics of dihydroartemisinin and piperaquine in pregnant and nonpregnant women with uncomplicated falciparum malaria.
by: Rijken, M, et al.
Published: (2011)

Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria.
by: Tarning, J, et al.
Published: (2012)

Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria
by: Tarning, J, et al.
Published: (2012)

Artesunate plus sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in Sudan
by: Ahmed Elderderi S, et al.
Published: (2005-09-01)

A randomised controlled trial of 3 versus 5 days artemether-lumefantrine regimen for uncomplicated Plasmodium falciparum treatment in pregnancy in Africa
by: Onyamboko, M, et al.
Published: (2019)

Pharmacokinetics of co-formulated mefloquine and artesunate in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum infection in Burkina Faso.
by: Valea, I, et al.
Published: (2014)

Artemisinin-based combination therapy for uncomplicated <it>Plasmodium falciparum </it>malaria in Colombia
by: Taylor Walter RJ, et al.
Published: (2007-02-01)

Travel as a risk factor for uncomplicated Plasmodium falciparum malaria in the highlands of western Kenya.
by: Shanks, G, et al.
Published: (2005)

Efficacy and safety of dihydroartemisinin-piperaquine in Indonesian children infected with uncomplicated Plasmodium falciparum and Plasmodium vivax
by: Emiliana Tjitra, et al.
Published: (2011-12-01)

Oral artesunate in the treatment of uncomplicated hyperparasitemic falciparum malaria.
by: Luxemburger, C, et al.
Published: (1995)

Therapeutic efficacies of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum and chloroquine and dihydroartemisinin-piperaquine for uncomplicated Plasmodium vivax infection in Ethiopia
by: Ashenafi Assefa, et al.
Published: (2022-12-01)

A randomised controlled trial of artemether-lumefantrine versus artesunate for uncomplicated plasmodium falciparum treatment in pregnancy.
by: Mcgready, R, et al.
Published: (2008)

Comparison of plasma, venous and capillary blood levels of piperaquine in patients with uncomplicated falciparum malaria.
by: Ashley, E, et al.
Published: (2010)

Optimising statistical methodologies for estimating antimalarial efficacy for uncomplicated Plasmodium falciparum malaria
by: Dahal, P
Published: (2018)

Efficacy of artesunate-amodiaquine for treatment of uncomplicated Plasmodium falciparum malaria in mainland Tanzania
by: Billy Ngasala, et al.
Published: (2024-03-01)

Hemolysis after Oral Artemisinin Combination Therapy for Uncomplicated Plasmodium falciparum Malaria
by: Florian Kurth, et al.
Published: (2016-08-01)