Reaching the end-game for GWAS: Machine learning approaches for the prioritization of complex disease loci

Genome-wide association studies (GWAS) have revealed thousands of genetic loci that underpin the complex biology of many human traits. However, the strength of GWAS – the ability to detect genetic association by linkage disequilibrium (LD) – is also its limitation. Whilst the ever-increasing study s...

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Detalhes bibliográficos
Main Authors: Nicholls, HL, John, CR, Watson, DS, Munroe, PB, Barnes, MR, Cabrera, CP
Formato: Journal article
Idioma:English
Publicado em: Frontiers 2020