Autoimmune disease preceding amyotrophic lateral sclerosis: an epidemiologic study.
OBJECTIVE: To study whether the risk of amyotrophic lateral sclerosis (ALS) is increased in people with prior autoimmune disease. METHODS: An all-England hospital record-linkage dataset spanning 1999-2011 was used. Cohorts were constructed of people with each of a range of autoimmune diseases; the i...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2013
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| _version_ | 1826280574422089728 |
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| author | Turner, M Goldacre, R Ramagopalan, S Talbot, K Goldacre, M |
| author_facet | Turner, M Goldacre, R Ramagopalan, S Talbot, K Goldacre, M |
| author_sort | Turner, M |
| collection | OXFORD |
| description | OBJECTIVE: To study whether the risk of amyotrophic lateral sclerosis (ALS) is increased in people with prior autoimmune disease. METHODS: An all-England hospital record-linkage dataset spanning 1999-2011 was used. Cohorts were constructed of people with each of a range of autoimmune diseases; the incidence of ALS in each disease cohort was compared with the incidence of ALS in a cohort of individuals without prior admission for the autoimmune disease. RESULTS: There were significantly more cases than expected of ALS associated with a prior diagnosis of asthma, celiac disease, younger-onset diabetes (younger than 30 years), multiple sclerosis, myasthenia gravis, myxedema, polymyositis, Sjögren syndrome, systemic lupus erythematosus, and ulcerative colitis. CONCLUSIONS: Autoimmune disease associations with ALS raise the possibility of shared genetic or environmental risk factors. |
| first_indexed | 2024-03-07T00:15:44Z |
| format | Journal article |
| id | oxford-uuid:7ac81280-fab3-4984-bec3-18f4e88db89f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:15:44Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:7ac81280-fab3-4984-bec3-18f4e88db89f2022-03-26T20:46:15ZAutoimmune disease preceding amyotrophic lateral sclerosis: an epidemiologic study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7ac81280-fab3-4984-bec3-18f4e88db89fEnglishSymplectic Elements at Oxford2013Turner, MGoldacre, RRamagopalan, STalbot, KGoldacre, MOBJECTIVE: To study whether the risk of amyotrophic lateral sclerosis (ALS) is increased in people with prior autoimmune disease. METHODS: An all-England hospital record-linkage dataset spanning 1999-2011 was used. Cohorts were constructed of people with each of a range of autoimmune diseases; the incidence of ALS in each disease cohort was compared with the incidence of ALS in a cohort of individuals without prior admission for the autoimmune disease. RESULTS: There were significantly more cases than expected of ALS associated with a prior diagnosis of asthma, celiac disease, younger-onset diabetes (younger than 30 years), multiple sclerosis, myasthenia gravis, myxedema, polymyositis, Sjögren syndrome, systemic lupus erythematosus, and ulcerative colitis. CONCLUSIONS: Autoimmune disease associations with ALS raise the possibility of shared genetic or environmental risk factors. |
| spellingShingle | Turner, M Goldacre, R Ramagopalan, S Talbot, K Goldacre, M Autoimmune disease preceding amyotrophic lateral sclerosis: an epidemiologic study. |
| title | Autoimmune disease preceding amyotrophic lateral sclerosis: an epidemiologic study. |
| title_full | Autoimmune disease preceding amyotrophic lateral sclerosis: an epidemiologic study. |
| title_fullStr | Autoimmune disease preceding amyotrophic lateral sclerosis: an epidemiologic study. |
| title_full_unstemmed | Autoimmune disease preceding amyotrophic lateral sclerosis: an epidemiologic study. |
| title_short | Autoimmune disease preceding amyotrophic lateral sclerosis: an epidemiologic study. |
| title_sort | autoimmune disease preceding amyotrophic lateral sclerosis an epidemiologic study |
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