The Promise and the hype of 'personalised medicine'
Personalised medicine is widely considered as the way of the future for medicine. However, progress in cancer, with a few outstanding exceptions, has fallen below expectations because of the challenges of tumour heterogeneity and clonal evolution. In both benign and malignant disease, diseases cause...
| Main Author: | |
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| Format: | Journal article |
| Language: | English |
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Taylor and Francis
2017
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| _version_ | 1826280575221104640 |
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| author | Maughan, T |
| author_facet | Maughan, T |
| author_sort | Maughan, T |
| collection | OXFORD |
| description | Personalised medicine is widely considered as the way of the future for medicine. However, progress in cancer, with a few outstanding exceptions, has fallen below expectations because of the challenges of tumour heterogeneity and clonal evolution. In both benign and malignant disease, diseases caused by single genetic alterations are more amenable to precision medicine approaches. However, most common diseases are caused by a complex interplay of multiple genetic and environmental factors making personalised medicine far more challenging. The current optimism for personalised medicine is distorting clinical consultations, resource allocation and research funding prioritisation. A research active clinician must act both as an agent of change and development, and as a communicator of realism. Thus personalised medicine that includes a sober appreciation of what genomics can achieve, together with continued focus on the individual as a person not just as a genome, will contribute to further improvements in health and healthcare. |
| first_indexed | 2024-03-07T00:15:45Z |
| format | Journal article |
| id | oxford-uuid:7ac862e7-ad8b-41d9-a766-a41db3dd1297 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:15:45Z |
| publishDate | 2017 |
| publisher | Taylor and Francis |
| record_format | dspace |
| spelling | oxford-uuid:7ac862e7-ad8b-41d9-a766-a41db3dd12972022-03-26T20:46:16ZThe Promise and the hype of 'personalised medicine'Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7ac862e7-ad8b-41d9-a766-a41db3dd1297EnglishSymplectic Elements at OxfordTaylor and Francis2017Maughan, TPersonalised medicine is widely considered as the way of the future for medicine. However, progress in cancer, with a few outstanding exceptions, has fallen below expectations because of the challenges of tumour heterogeneity and clonal evolution. In both benign and malignant disease, diseases caused by single genetic alterations are more amenable to precision medicine approaches. However, most common diseases are caused by a complex interplay of multiple genetic and environmental factors making personalised medicine far more challenging. The current optimism for personalised medicine is distorting clinical consultations, resource allocation and research funding prioritisation. A research active clinician must act both as an agent of change and development, and as a communicator of realism. Thus personalised medicine that includes a sober appreciation of what genomics can achieve, together with continued focus on the individual as a person not just as a genome, will contribute to further improvements in health and healthcare. |
| spellingShingle | Maughan, T The Promise and the hype of 'personalised medicine' |
| title | The Promise and the hype of 'personalised medicine' |
| title_full | The Promise and the hype of 'personalised medicine' |
| title_fullStr | The Promise and the hype of 'personalised medicine' |
| title_full_unstemmed | The Promise and the hype of 'personalised medicine' |
| title_short | The Promise and the hype of 'personalised medicine' |
| title_sort | promise and the hype of personalised medicine |
| work_keys_str_mv | AT maughant thepromiseandthehypeofpersonalisedmedicine AT maughant promiseandthehypeofpersonalisedmedicine |