High prevalence of hospital-acquired infections caused by gram-negative carbapenem resistant strains in Vietnamese pediatric ICUs: A multi-centre point prevalence survey
There is scarce information regarding hospital-acquired infections (HAIs) among children in resource-constrained settings. This study aims to measure prevalence of HAIs in Vietnamese pediatric hospitals.Monthly point prevalence surveys (PPSs) in 6 pediatric intensive care units (ICUs) in 3 referral...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Lippincott, Williams & Wilkins
2016
|
| _version_ | 1826280590656143360 |
|---|---|
| author | Le, N Hf, W Vu, P Khu, D Le, H Hoang, B Vo, V Lam, Y Vu, D Nguyen, T Thai, T Nilsson, L Rydell, U Nguyen, K Nadjm, B Clarkson, L Hanberger, H Larsson, M |
| author_facet | Le, N Hf, W Vu, P Khu, D Le, H Hoang, B Vo, V Lam, Y Vu, D Nguyen, T Thai, T Nilsson, L Rydell, U Nguyen, K Nadjm, B Clarkson, L Hanberger, H Larsson, M |
| author_sort | Le, N |
| collection | OXFORD |
| description | There is scarce information regarding hospital-acquired infections (HAIs) among children in resource-constrained settings. This study aims to measure prevalence of HAIs in Vietnamese pediatric hospitals.Monthly point prevalence surveys (PPSs) in 6 pediatric intensive care units (ICUs) in 3 referral hospitals during 1 year.A total of 1363 cases (1143 children) were surveyed, 59.9% male, average age 11 months. Admission sources were: other hospital 49.3%, current hospital 36.5%, and community 15.3%. Reasons for admission were: infectious disease (66%), noninfectious (20.8%), and surgery/trauma (11.3%). Intubation rate was 47.8%, central venous catheter 29.4%, peripheral venous catheter 86.2%, urinary catheter 14.6%, and hemodialysis/filtration 1.7%. HAI was diagnosed in 33.1% of the cases: pneumonia (52.2%), septicemia (26.4%), surgical site infection (2%), and necrotizing enterocolitis (2%). Significant risk factors for HAI included age under 7 months, intubation and infection at admission. Microbiological findings were reported in 212 cases (43%) with 276 isolates: 50 Klebsiella pneumoniae, 46 Pseudomonas aeruginosa, and 39 Acinetobacter baumannii, with carbapenem resistance detected in 55%, 71%, and 65%, respectively. Staphylococcus aureus was cultured in 18 cases, with 81% methicillin-resistant Staphylococcus aureus. Most children (87.6%) received antibiotics, with an average of 1.6 antibiotics per case. Colistin was administered to 96 patients, 93% with HAI and 49% with culture confirmed carbapenem resistance.The high prevalence of HAI with carbapenem resistant gram-negative strains and common treatment with broad-spectrum antibiotics and colistin suggests that interventions are needed to prevent HAI and to optimize antibiotic use. |
| first_indexed | 2024-03-07T00:15:58Z |
| format | Journal article |
| id | oxford-uuid:7ad832de-92e9-42a5-99c4-bd81e958e52c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:15:58Z |
| publishDate | 2016 |
| publisher | Lippincott, Williams & Wilkins |
| record_format | dspace |
| spelling | oxford-uuid:7ad832de-92e9-42a5-99c4-bd81e958e52c2022-03-26T20:46:44ZHigh prevalence of hospital-acquired infections caused by gram-negative carbapenem resistant strains in Vietnamese pediatric ICUs: A multi-centre point prevalence surveyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7ad832de-92e9-42a5-99c4-bd81e958e52cEnglishSymplectic Elements at OxfordLippincott, Williams & Wilkins2016Le, NHf, WVu, PKhu, DLe, HHoang, BVo, VLam, YVu, DNguyen, TThai, TNilsson, LRydell, UNguyen, KNadjm, BClarkson, LHanberger, HLarsson, MThere is scarce information regarding hospital-acquired infections (HAIs) among children in resource-constrained settings. This study aims to measure prevalence of HAIs in Vietnamese pediatric hospitals.Monthly point prevalence surveys (PPSs) in 6 pediatric intensive care units (ICUs) in 3 referral hospitals during 1 year.A total of 1363 cases (1143 children) were surveyed, 59.9% male, average age 11 months. Admission sources were: other hospital 49.3%, current hospital 36.5%, and community 15.3%. Reasons for admission were: infectious disease (66%), noninfectious (20.8%), and surgery/trauma (11.3%). Intubation rate was 47.8%, central venous catheter 29.4%, peripheral venous catheter 86.2%, urinary catheter 14.6%, and hemodialysis/filtration 1.7%. HAI was diagnosed in 33.1% of the cases: pneumonia (52.2%), septicemia (26.4%), surgical site infection (2%), and necrotizing enterocolitis (2%). Significant risk factors for HAI included age under 7 months, intubation and infection at admission. Microbiological findings were reported in 212 cases (43%) with 276 isolates: 50 Klebsiella pneumoniae, 46 Pseudomonas aeruginosa, and 39 Acinetobacter baumannii, with carbapenem resistance detected in 55%, 71%, and 65%, respectively. Staphylococcus aureus was cultured in 18 cases, with 81% methicillin-resistant Staphylococcus aureus. Most children (87.6%) received antibiotics, with an average of 1.6 antibiotics per case. Colistin was administered to 96 patients, 93% with HAI and 49% with culture confirmed carbapenem resistance.The high prevalence of HAI with carbapenem resistant gram-negative strains and common treatment with broad-spectrum antibiotics and colistin suggests that interventions are needed to prevent HAI and to optimize antibiotic use. |
| spellingShingle | Le, N Hf, W Vu, P Khu, D Le, H Hoang, B Vo, V Lam, Y Vu, D Nguyen, T Thai, T Nilsson, L Rydell, U Nguyen, K Nadjm, B Clarkson, L Hanberger, H Larsson, M High prevalence of hospital-acquired infections caused by gram-negative carbapenem resistant strains in Vietnamese pediatric ICUs: A multi-centre point prevalence survey |
| title | High prevalence of hospital-acquired infections caused by gram-negative carbapenem resistant strains in Vietnamese pediatric ICUs: A multi-centre point prevalence survey |
| title_full | High prevalence of hospital-acquired infections caused by gram-negative carbapenem resistant strains in Vietnamese pediatric ICUs: A multi-centre point prevalence survey |
| title_fullStr | High prevalence of hospital-acquired infections caused by gram-negative carbapenem resistant strains in Vietnamese pediatric ICUs: A multi-centre point prevalence survey |
| title_full_unstemmed | High prevalence of hospital-acquired infections caused by gram-negative carbapenem resistant strains in Vietnamese pediatric ICUs: A multi-centre point prevalence survey |
| title_short | High prevalence of hospital-acquired infections caused by gram-negative carbapenem resistant strains in Vietnamese pediatric ICUs: A multi-centre point prevalence survey |
| title_sort | high prevalence of hospital acquired infections caused by gram negative carbapenem resistant strains in vietnamese pediatric icus a multi centre point prevalence survey |
| work_keys_str_mv | AT len highprevalenceofhospitalacquiredinfectionscausedbygramnegativecarbapenemresistantstrainsinvietnamesepediatricicusamulticentrepointprevalencesurvey AT hfw highprevalenceofhospitalacquiredinfectionscausedbygramnegativecarbapenemresistantstrainsinvietnamesepediatricicusamulticentrepointprevalencesurvey AT vup highprevalenceofhospitalacquiredinfectionscausedbygramnegativecarbapenemresistantstrainsinvietnamesepediatricicusamulticentrepointprevalencesurvey AT khud highprevalenceofhospitalacquiredinfectionscausedbygramnegativecarbapenemresistantstrainsinvietnamesepediatricicusamulticentrepointprevalencesurvey AT leh highprevalenceofhospitalacquiredinfectionscausedbygramnegativecarbapenemresistantstrainsinvietnamesepediatricicusamulticentrepointprevalencesurvey AT hoangb highprevalenceofhospitalacquiredinfectionscausedbygramnegativecarbapenemresistantstrainsinvietnamesepediatricicusamulticentrepointprevalencesurvey AT vov highprevalenceofhospitalacquiredinfectionscausedbygramnegativecarbapenemresistantstrainsinvietnamesepediatricicusamulticentrepointprevalencesurvey AT lamy highprevalenceofhospitalacquiredinfectionscausedbygramnegativecarbapenemresistantstrainsinvietnamesepediatricicusamulticentrepointprevalencesurvey AT vud highprevalenceofhospitalacquiredinfectionscausedbygramnegativecarbapenemresistantstrainsinvietnamesepediatricicusamulticentrepointprevalencesurvey AT nguyent highprevalenceofhospitalacquiredinfectionscausedbygramnegativecarbapenemresistantstrainsinvietnamesepediatricicusamulticentrepointprevalencesurvey AT thait highprevalenceofhospitalacquiredinfectionscausedbygramnegativecarbapenemresistantstrainsinvietnamesepediatricicusamulticentrepointprevalencesurvey AT nilssonl highprevalenceofhospitalacquiredinfectionscausedbygramnegativecarbapenemresistantstrainsinvietnamesepediatricicusamulticentrepointprevalencesurvey AT rydellu highprevalenceofhospitalacquiredinfectionscausedbygramnegativecarbapenemresistantstrainsinvietnamesepediatricicusamulticentrepointprevalencesurvey AT nguyenk highprevalenceofhospitalacquiredinfectionscausedbygramnegativecarbapenemresistantstrainsinvietnamesepediatricicusamulticentrepointprevalencesurvey AT nadjmb highprevalenceofhospitalacquiredinfectionscausedbygramnegativecarbapenemresistantstrainsinvietnamesepediatricicusamulticentrepointprevalencesurvey AT clarksonl highprevalenceofhospitalacquiredinfectionscausedbygramnegativecarbapenemresistantstrainsinvietnamesepediatricicusamulticentrepointprevalencesurvey AT hanbergerh highprevalenceofhospitalacquiredinfectionscausedbygramnegativecarbapenemresistantstrainsinvietnamesepediatricicusamulticentrepointprevalencesurvey AT larssonm highprevalenceofhospitalacquiredinfectionscausedbygramnegativecarbapenemresistantstrainsinvietnamesepediatricicusamulticentrepointprevalencesurvey |