Glycosylation catalyzed by a chiral Bronsted acid.
The use of a chiral Brønsted acid catalyst for the activation of trichloroacetimidate glycosyl donors has been demonstrated for the first time. In toluene the chirality of the acid catalyst is seen to influence the stereochemical outcome of the glycosylation processes, hinting that perhaps diastereo...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1826280596385562624 |
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| author | Cox, D Smith, M Fairbanks, A |
| author_facet | Cox, D Smith, M Fairbanks, A |
| author_sort | Cox, D |
| collection | OXFORD |
| description | The use of a chiral Brønsted acid catalyst for the activation of trichloroacetimidate glycosyl donors has been demonstrated for the first time. In toluene the chirality of the acid catalyst is seen to influence the stereochemical outcome of the glycosylation processes, hinting that perhaps diastereocontrol of glycosylation processes may become achievable through the judicious use of chiral organic catalysts. |
| first_indexed | 2024-03-07T00:16:04Z |
| format | Journal article |
| id | oxford-uuid:7adebeaa-1a57-4938-9ac0-5ed6c782fd8c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:16:04Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:7adebeaa-1a57-4938-9ac0-5ed6c782fd8c2022-03-26T20:46:54ZGlycosylation catalyzed by a chiral Bronsted acid.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7adebeaa-1a57-4938-9ac0-5ed6c782fd8cEnglishSymplectic Elements at Oxford2010Cox, DSmith, MFairbanks, AThe use of a chiral Brønsted acid catalyst for the activation of trichloroacetimidate glycosyl donors has been demonstrated for the first time. In toluene the chirality of the acid catalyst is seen to influence the stereochemical outcome of the glycosylation processes, hinting that perhaps diastereocontrol of glycosylation processes may become achievable through the judicious use of chiral organic catalysts. |
| spellingShingle | Cox, D Smith, M Fairbanks, A Glycosylation catalyzed by a chiral Bronsted acid. |
| title | Glycosylation catalyzed by a chiral Bronsted acid. |
| title_full | Glycosylation catalyzed by a chiral Bronsted acid. |
| title_fullStr | Glycosylation catalyzed by a chiral Bronsted acid. |
| title_full_unstemmed | Glycosylation catalyzed by a chiral Bronsted acid. |
| title_short | Glycosylation catalyzed by a chiral Bronsted acid. |
| title_sort | glycosylation catalyzed by a chiral bronsted acid |
| work_keys_str_mv | AT coxd glycosylationcatalyzedbyachiralbronstedacid AT smithm glycosylationcatalyzedbyachiralbronstedacid AT fairbanksa glycosylationcatalyzedbyachiralbronstedacid |