Heterogeneity in Ewing sarcoma
<p>Ewing sarcoma, an aggressive primary bone and soft tissue tumour is characterised by the expression of the chimeric transcription factor EWS-FLI1 in 90% of patients. This alters expression of many genes including activation of the Insulin Growth Factor (IGF) pathway via IGFBP3 supression. P...
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| Médium: | Diplomová práce |
| Jazyk: | English |
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2014
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