Emergence of untreatable, multidrug-resistant HIV-1 in patients failing second-line therapy in Kenya
We performed a countrywide assessment of HIV drug resistance among 123 patients with virological failure on second-line antiretroviral therapy (ART) in Kenya. The percentage of patients harbouring intermediate-to-high-level resistance was 27% for lopinavir-ritonavir, 24% for atazanavir-ritonavir and...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Lippincott, Williams & Wilkins
2017
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| _version_ | 1797077350353993728 |
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| author | Inzaule, S Hamers, R Mukui, I Were, K Owiti, P Kwaro, D de Wit, T Zeh, C |
| author_facet | Inzaule, S Hamers, R Mukui, I Were, K Owiti, P Kwaro, D de Wit, T Zeh, C |
| author_sort | Inzaule, S |
| collection | OXFORD |
| description | We performed a countrywide assessment of HIV drug resistance among 123 patients with virological failure on second-line antiretroviral therapy (ART) in Kenya. The percentage of patients harbouring intermediate-to-high-level resistance was 27% for lopinavir-ritonavir, 24% for atazanavir-ritonavir and 7% for darunavir-ritonavir, and 25% had complete loss of activity to all available first and secondline drugs. Overall, one in four patients failing second-line ART have completely exhausted available antiretrovirals in Kenya, highlighting the need for increased access to third-line drugs. |
| first_indexed | 2024-03-07T00:16:40Z |
| format | Journal article |
| id | oxford-uuid:7b1242b0-ef0b-411a-bf35-28ea2a2e5634 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:16:40Z |
| publishDate | 2017 |
| publisher | Lippincott, Williams & Wilkins |
| record_format | dspace |
| spelling | oxford-uuid:7b1242b0-ef0b-411a-bf35-28ea2a2e56342022-03-26T20:48:15ZEmergence of untreatable, multidrug-resistant HIV-1 in patients failing second-line therapy in KenyaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7b1242b0-ef0b-411a-bf35-28ea2a2e5634EnglishSymplectic Elements at OxfordLippincott, Williams & Wilkins2017Inzaule, SHamers, RMukui, IWere, KOwiti, PKwaro, Dde Wit, TZeh, CWe performed a countrywide assessment of HIV drug resistance among 123 patients with virological failure on second-line antiretroviral therapy (ART) in Kenya. The percentage of patients harbouring intermediate-to-high-level resistance was 27% for lopinavir-ritonavir, 24% for atazanavir-ritonavir and 7% for darunavir-ritonavir, and 25% had complete loss of activity to all available first and secondline drugs. Overall, one in four patients failing second-line ART have completely exhausted available antiretrovirals in Kenya, highlighting the need for increased access to third-line drugs. |
| spellingShingle | Inzaule, S Hamers, R Mukui, I Were, K Owiti, P Kwaro, D de Wit, T Zeh, C Emergence of untreatable, multidrug-resistant HIV-1 in patients failing second-line therapy in Kenya |
| title | Emergence of untreatable, multidrug-resistant HIV-1 in patients failing second-line therapy in Kenya |
| title_full | Emergence of untreatable, multidrug-resistant HIV-1 in patients failing second-line therapy in Kenya |
| title_fullStr | Emergence of untreatable, multidrug-resistant HIV-1 in patients failing second-line therapy in Kenya |
| title_full_unstemmed | Emergence of untreatable, multidrug-resistant HIV-1 in patients failing second-line therapy in Kenya |
| title_short | Emergence of untreatable, multidrug-resistant HIV-1 in patients failing second-line therapy in Kenya |
| title_sort | emergence of untreatable multidrug resistant hiv 1 in patients failing second line therapy in kenya |
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