CD161 defines a functionally distinct subset of pro-inflammatory natural killer cells
CD161 is a C-type lectin-like receptor expressed on the majority of natural killer (NK) cells; however, the significance of CD161 expression on NK cells has not been comprehensively investigated. Recently, we found that CD161 expression identifies a transcriptional and innate functional phenotype th...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
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Frontiers Media
2018
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| _version_ | 1797077356564709376 |
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| author | Kurioka, A Cosgrove, C Simoni, Y van Wilgenburg, B Geremia, A Björkander, S Sverremark-Ekström, E Thurnheer, C Günthard, H Khanna, N Swiss HIV Cohort Study (50 Others) Oxford IBD Cohort Investigators et al. Walker, L Arancibia-Cárcamo, C Newell, E Willberg, C Klenerman, P |
| author_facet | Kurioka, A Cosgrove, C Simoni, Y van Wilgenburg, B Geremia, A Björkander, S Sverremark-Ekström, E Thurnheer, C Günthard, H Khanna, N Swiss HIV Cohort Study (50 Others) Oxford IBD Cohort Investigators et al. Walker, L Arancibia-Cárcamo, C Newell, E Willberg, C Klenerman, P |
| author_sort | Kurioka, A |
| collection | OXFORD |
| description | CD161 is a C-type lectin-like receptor expressed on the majority of natural killer (NK) cells; however, the significance of CD161 expression on NK cells has not been comprehensively investigated. Recently, we found that CD161 expression identifies a transcriptional and innate functional phenotype that is shared across various T cell populations. Using mass cytometry and microarray experiments, we demonstrate that this functional phenotype extends to NK cells. CD161 marks NK cells that have retained the ability to respond to innate cytokines during their differentiation, and is lost upon cytomegalovirus-induced maturation in both healthy and human immunodeficiency virus (HIV)-infected patients. These pro-inflammatory NK cells are present in the inflamed lamina propria where they are enriched for integrin CD103 expression. Thus, CD161 expression identifies NK cells that may contribute to inflammatory disease pathogenesis and correlates with an innate responsiveness to cytokines in both T and NK cells. |
| first_indexed | 2024-03-07T00:16:46Z |
| format | Journal article |
| id | oxford-uuid:7b1cfa40-41ce-4bac-9cb5-b89d864e3336 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T00:16:46Z |
| publishDate | 2018 |
| publisher | Frontiers Media |
| record_format | dspace |
| spelling | oxford-uuid:7b1cfa40-41ce-4bac-9cb5-b89d864e33362022-03-26T20:48:37ZCD161 defines a functionally distinct subset of pro-inflammatory natural killer cellsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7b1cfa40-41ce-4bac-9cb5-b89d864e3336Symplectic Elements at OxfordFrontiers Media2018Kurioka, ACosgrove, CSimoni, Yvan Wilgenburg, BGeremia, ABjörkander, SSverremark-Ekström, EThurnheer, CGünthard, HKhanna, NSwiss HIV Cohort Study (50 Others)Oxford IBD Cohort Investigators et al.Walker, LArancibia-Cárcamo, CNewell, EWillberg, CKlenerman, PCD161 is a C-type lectin-like receptor expressed on the majority of natural killer (NK) cells; however, the significance of CD161 expression on NK cells has not been comprehensively investigated. Recently, we found that CD161 expression identifies a transcriptional and innate functional phenotype that is shared across various T cell populations. Using mass cytometry and microarray experiments, we demonstrate that this functional phenotype extends to NK cells. CD161 marks NK cells that have retained the ability to respond to innate cytokines during their differentiation, and is lost upon cytomegalovirus-induced maturation in both healthy and human immunodeficiency virus (HIV)-infected patients. These pro-inflammatory NK cells are present in the inflamed lamina propria where they are enriched for integrin CD103 expression. Thus, CD161 expression identifies NK cells that may contribute to inflammatory disease pathogenesis and correlates with an innate responsiveness to cytokines in both T and NK cells. |
| spellingShingle | Kurioka, A Cosgrove, C Simoni, Y van Wilgenburg, B Geremia, A Björkander, S Sverremark-Ekström, E Thurnheer, C Günthard, H Khanna, N Swiss HIV Cohort Study (50 Others) Oxford IBD Cohort Investigators et al. Walker, L Arancibia-Cárcamo, C Newell, E Willberg, C Klenerman, P CD161 defines a functionally distinct subset of pro-inflammatory natural killer cells |
| title | CD161 defines a functionally distinct subset of pro-inflammatory natural killer cells |
| title_full | CD161 defines a functionally distinct subset of pro-inflammatory natural killer cells |
| title_fullStr | CD161 defines a functionally distinct subset of pro-inflammatory natural killer cells |
| title_full_unstemmed | CD161 defines a functionally distinct subset of pro-inflammatory natural killer cells |
| title_short | CD161 defines a functionally distinct subset of pro-inflammatory natural killer cells |
| title_sort | cd161 defines a functionally distinct subset of pro inflammatory natural killer cells |
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