Pharmacological mechanisms and animal models of cognition.
Requirements for an effective animal model of cognition are discussed with special reference to the cholinergic hypothesis of Alzheimer's disease. It is argued, with reference to research on vasopressin and ACE inhibitors, that many putative animal models of cognition lack predictive clinical v...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1992
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| _version_ | 1797077368836194304 |
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| author | Dawson, G Heyes, C Iversen, S |
| author_facet | Dawson, G Heyes, C Iversen, S |
| author_sort | Dawson, G |
| collection | OXFORD |
| description | Requirements for an effective animal model of cognition are discussed with special reference to the cholinergic hypothesis of Alzheimer's disease. It is argued, with reference to research on vasopressin and ACE inhibitors, that many putative animal models of cognition lack predictive clinical validity because they either confound the effects of cognitive and arousal processes, or fail to model a specific component of cognitive functioning. A survey of recent research on the cholinergic hypothesis illustrates how these weaknesses can be overcome. Studies involving scopolamine and basal forebrain excitatory amino acid lesion models of the cholinergic deficit in Alzheimer's disease have employed a delayed-matching-to-position test in rodents which, unlike passive avoidance, allows the effects of memory and attentional variables to be distinguished. In combination with recent human studies, these experiments suggest that the cholinergic system has a major role in executive control of attentional resources, and lead to the recommendation of a 'top down' strategy in the investigation of neurochemical processes and pharmacological mechanisms underlying cognition. |
| first_indexed | 2024-03-07T00:16:57Z |
| format | Journal article |
| id | oxford-uuid:7b2d881e-75df-4b03-8b5b-a5c2f532b4ce |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:16:57Z |
| publishDate | 1992 |
| record_format | dspace |
| spelling | oxford-uuid:7b2d881e-75df-4b03-8b5b-a5c2f532b4ce2022-03-26T20:48:54ZPharmacological mechanisms and animal models of cognition.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7b2d881e-75df-4b03-8b5b-a5c2f532b4ceEnglishSymplectic Elements at Oxford1992Dawson, GHeyes, CIversen, SRequirements for an effective animal model of cognition are discussed with special reference to the cholinergic hypothesis of Alzheimer's disease. It is argued, with reference to research on vasopressin and ACE inhibitors, that many putative animal models of cognition lack predictive clinical validity because they either confound the effects of cognitive and arousal processes, or fail to model a specific component of cognitive functioning. A survey of recent research on the cholinergic hypothesis illustrates how these weaknesses can be overcome. Studies involving scopolamine and basal forebrain excitatory amino acid lesion models of the cholinergic deficit in Alzheimer's disease have employed a delayed-matching-to-position test in rodents which, unlike passive avoidance, allows the effects of memory and attentional variables to be distinguished. In combination with recent human studies, these experiments suggest that the cholinergic system has a major role in executive control of attentional resources, and lead to the recommendation of a 'top down' strategy in the investigation of neurochemical processes and pharmacological mechanisms underlying cognition. |
| spellingShingle | Dawson, G Heyes, C Iversen, S Pharmacological mechanisms and animal models of cognition. |
| title | Pharmacological mechanisms and animal models of cognition. |
| title_full | Pharmacological mechanisms and animal models of cognition. |
| title_fullStr | Pharmacological mechanisms and animal models of cognition. |
| title_full_unstemmed | Pharmacological mechanisms and animal models of cognition. |
| title_short | Pharmacological mechanisms and animal models of cognition. |
| title_sort | pharmacological mechanisms and animal models of cognition |
| work_keys_str_mv | AT dawsong pharmacologicalmechanismsandanimalmodelsofcognition AT heyesc pharmacologicalmechanismsandanimalmodelsofcognition AT iversens pharmacologicalmechanismsandanimalmodelsofcognition |