Chemical cross-linking stabilizes native-like HIV-1 envelope glycoprotein trimer antigens

Chemical cross-linking stabilizes native-like HIV-1 envelope glycoprotein trimer antigens

Major neutralizing antibody immune evasion strategies of the HIV-1 envelope glycoprotein (Env) trimer include conformational and structural instability. Stabilized soluble trimers such as BG505 SOSIP.664 mimic the structure of virion-associated Env but nevertheless sample different conformational st...

Full description

Bibliographic Details
Main Authors:	Schiffner, T, de Val, N, Russell, RA, de Taeye, SW, de la Peña, AT, Ozorowski, G, Kim, HJ, Nieusma, T, Brod, F, Cupo, A, Sanders, RW, Moore, JP, Ward, AB, Sattentau, QJ
Format:	Journal article
Language:	English
Published:	American Society for Microbiology 2015

Similar Items

Engineering and characterization of a fluorescent native-like HIV-1 envelope glycoprotein trimer
by: Pritchard, L, et al.
Published: (2015)

Influences on the design and purification of soluble, recombinant native-like HIV-1 envelope glycoprotein trimers
by: Ringe, R, et al.
Published: (2015)

Stabilized HIV-1 envelope glycoprotein trimers for vaccine use.
by: Medina-Ramírez, M, et al.
Published: (2017)

Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins
by: Schiffner, T, et al.
Published: (2018)

HIV-1-neutralizing antibody induced by simian adenovirus- and poxvirus MVA-vectored BG505 native-like envelope trimers
by: Capucci, S, et al.
Published: (2017)

HIV-1-neutralizing antibody 1 induced by simian adenovirus- and poxvirus MVA-vectored BG505 native-like envelope trimers
by: Capucci, S, et al.
Published: (2017)

Structural constraints determine the glycosylation of HIV-1 envelope trimers
by: Pritchard, L, et al.
Published: (2015)

Molecular architecture of the cleavage-dependent mannose patch on a soluble HIV-1 envelope glycoprotein trimer
by: Crispin, M, et al.
Published: (2016)

Composition and antigenic effects of individual glycan sites of a trimeric HIV-1 envelope glycoprotein
by: Crispin, M, et al.
Published: (2016)

Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization
by: Turner, Hannah L., et al.
Published: (2021)

Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies
by: McCoy, Laura E., et al.
Published: (2016)

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes.
by: de Taeye, S, et al.
Published: (2015)

Reducing V3 antigenicity and immunogenicity on soluble, native-like HIV-1 Env SOSIP trimers
by: Ringe, RP, et al.
Published: (2017)

The role of the envelope glycoproteins in HIV-1 transmission and pathogenesis
by: Sattentau, Q
Published: (1996)

A triply divergent reagent for glycoprotein synthesis
by: De Munari, S, et al.
Published: (2015)

Two distinct trimeric conformations of natively membrane-anchored full-length herpes simplex virus 1 glycoprotein B
by: Zeev-Ben-Mordehai, T, et al.
Published: (2016)

Integrity of glycosylation processing of a glycan-depleted trimeric HIV-1 immunogen targeting key B-cell lineages
by: Behrens, AJ, et al.
Published: (2018)

STRUCTURAL-ANALYSIS OF THE HIV-1 ENVELOPE GLYCOPROTEIN GP120
by: Moore, J, et al.
Published: (1993)

Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding.
by: Sattentau, Q, et al.
Published: (1991)

Structural studies of pestivirus envelope glycoproteins
by: Aitkenhead, H
Published: (2021)

Towards a structure of the HIV-1 envelope glycoprotein gp120: an immunochemical approach.
by: Moore, J, et al.
Published: (1993)

Oligomeric modeling and electrostatic analysis of the gp120 envelope glycoprotein of human immunodeficiency virus.
by: Kwong, P, et al.
Published: (2000)

Conformational transitions in CD4 due to complexation with HIV envelope glycoprotein gp120.
by: Denisova, G, et al.
Published: (1997)

Elimination of retroviral infectivity by N-ethylmaleimide with preservation of functional envelope glycoproteins.
by: Morcock, DR, et al.
Published: (2005)

Heparan sulfate targets the HIV-1 envelope glycoprotein gp120 coreceptor binding site.
by: Vivès, R, et al.
Published: (2005)

Conformational changes induced in the envelope glycoproteins of the human and simian immunodeficiency viruses by soluble receptor binding.
by: Sattentau, Q, et al.
Published: (1993)

Native functionality and therapeutic targeting of arenaviral glycoproteins.
by: Crispin, M, et al.
Published: (2016)

Native functionality and therapeutic targeting of arenaviral glycoproteins
by: Crispin, M, et al.
Published: (2016)

Expression-system-dependent modulation of HIV-1 envelope glycoprotein antigenicity and immunogenicity.
by: Kong, L, et al.
Published: (2010)

Expression-System-Dependent Modulation of HIV-1 Envelope Glycoprotein Antigenicity and Immunogenicity
by: Kong, L, et al.
Published: (2010)

Expression and characterisation of recombinant oligomeric envelope glycoproteins derived from primary isolates of HIV-1.
by: Jeffs, SA, et al.
Published: (2004)

Structural transitions of the conserved and metastable hantaviral glycoprotein envelope
by: Rissanen, I, et al.
Published: (2017)

Neutralizing antibodies to human immunodeficiency virus type-1 gp120 induce envelope glycoprotein subunit dissociation.
by: Poignard, P, et al.
Published: (1996)

A PLATINUM-LINKED CYCLIC PORPHYRIN TRIMER
by: Mackay, L, et al.
Published: (1992)

Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes
by: Kulp, Daniel W., et al.
Published: (2019)

Mutations within the CD4-CDR-3-like loop allow replication in an immortalized T cell line of HIV type 1 viruses chimeric for envelope glycoproteins containing non-syncytium-inducing V3 loops.
by: Signoret, N, et al.
Published: (1997)

Immunogenic recombinant Mayaro virus-like particles present natively assembled glycoprotein
by: Kim, YC, et al.
Published: (2024)

Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies
by: LaBranche, C, et al.
Published: (2019)

How good is HIV envelope glycoprotein vaccine as a T-lymphocyte stimulant?
by: Michie, C, et al.
Published: (1991)

LIGAND-BINDING BY BUTADIYNE-LINKED PORPHYRIA DIMERS, TRIMERS AND TETRAMERS
by: Anderson, H, et al.
Published: (1995)