Chemical cross-linking stabilizes native-like HIV-1 envelope glycoprotein trimer antigens

Major neutralizing antibody immune evasion strategies of the HIV-1 envelope glycoprotein (Env) trimer include conformational and structural instability. Stabilized soluble trimers such as BG505 SOSIP.664 mimic the structure of virion-associated Env but nevertheless sample different conformational st...

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Những tác giả chính:	Schiffner, T, de Val, N, Russell, RA, de Taeye, SW, de la Peña, AT, Ozorowski, G, Kim, HJ, Nieusma, T, Brod, F, Cupo, A, Sanders, RW, Moore, JP, Ward, AB, Sattentau, QJ
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	American Society for Microbiology 2015

Chemical cross-linking stabilizes native-like HIV-1 envelope glycoprotein trimer antigens

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