Identification of host-pathogen-disease relationships using a scalable Multiplex Serology platform in UK Biobank
Certain infectious agents are recognised causes of cancer and other chronic diseases. To understand the pathological mechanisms underlying such relationships, here we design a Multiplex Serology platform to measure quantitative antibody responses against 45 antigens from 20 infectious agents includi...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2022
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| _version_ | 1797107183647719424 |
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| author | Mentzer, A Brenner, N Allen, N Littlejohns, T Chong, A Cortes, A Almond, R Hill, M Sheard, S McVean, G Collins, R Waterboer, T |
| author_facet | Mentzer, A Brenner, N Allen, N Littlejohns, T Chong, A Cortes, A Almond, R Hill, M Sheard, S McVean, G Collins, R Waterboer, T |
| author_sort | Mentzer, A |
| collection | OXFORD |
| description | Certain infectious agents are recognised causes of cancer and other chronic diseases. To understand the pathological mechanisms underlying such relationships, here we design a Multiplex Serology platform to measure quantitative antibody responses against 45 antigens from 20 infectious agents including human herpes, hepatitis, polyoma, papilloma, and retroviruses, as well as Chlamydia trachomatis, Helicobacter pylori and Toxoplasma gondii, then assayed a random subset of 9695 UK Biobank participants. We find seroprevalence estimates consistent with those expected from prior literature and confirm multiple associations of antibody responses with sociodemographic characteristics (e.g., lifetime sexual partners with C. trachomatis), HLA genetic variants (rs6927022 with Epstein-Barr virus (EBV) EBNA1 antibodies) and disease outcomes (human papillomavirus-16 seropositivity with cervical intraepithelial neoplasia, and EBV responses with multiple sclerosis). Our accessible dataset is one of the largest incorporating diverse infectious agents in a prospective UK cohort offering opportunities to improve our understanding of host-pathogen-disease relationships with significant clinical and public health implications. |
| first_indexed | 2024-03-07T07:10:54Z |
| format | Journal article |
| id | oxford-uuid:7b325dd6-7d18-4779-97f2-062a40a673dd |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:10:54Z |
| publishDate | 2022 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:7b325dd6-7d18-4779-97f2-062a40a673dd2022-06-24T15:44:09ZIdentification of host-pathogen-disease relationships using a scalable Multiplex Serology platform in UK BiobankJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7b325dd6-7d18-4779-97f2-062a40a673ddEnglishSymplectic ElementsSpringer Nature2022Mentzer, ABrenner, NAllen, NLittlejohns, TChong, ACortes, AAlmond, RHill, MSheard, SMcVean, GCollins, RWaterboer, TCertain infectious agents are recognised causes of cancer and other chronic diseases. To understand the pathological mechanisms underlying such relationships, here we design a Multiplex Serology platform to measure quantitative antibody responses against 45 antigens from 20 infectious agents including human herpes, hepatitis, polyoma, papilloma, and retroviruses, as well as Chlamydia trachomatis, Helicobacter pylori and Toxoplasma gondii, then assayed a random subset of 9695 UK Biobank participants. We find seroprevalence estimates consistent with those expected from prior literature and confirm multiple associations of antibody responses with sociodemographic characteristics (e.g., lifetime sexual partners with C. trachomatis), HLA genetic variants (rs6927022 with Epstein-Barr virus (EBV) EBNA1 antibodies) and disease outcomes (human papillomavirus-16 seropositivity with cervical intraepithelial neoplasia, and EBV responses with multiple sclerosis). Our accessible dataset is one of the largest incorporating diverse infectious agents in a prospective UK cohort offering opportunities to improve our understanding of host-pathogen-disease relationships with significant clinical and public health implications. |
| spellingShingle | Mentzer, A Brenner, N Allen, N Littlejohns, T Chong, A Cortes, A Almond, R Hill, M Sheard, S McVean, G Collins, R Waterboer, T Identification of host-pathogen-disease relationships using a scalable Multiplex Serology platform in UK Biobank |
| title | Identification of host-pathogen-disease relationships using a scalable Multiplex Serology platform in UK Biobank |
| title_full | Identification of host-pathogen-disease relationships using a scalable Multiplex Serology platform in UK Biobank |
| title_fullStr | Identification of host-pathogen-disease relationships using a scalable Multiplex Serology platform in UK Biobank |
| title_full_unstemmed | Identification of host-pathogen-disease relationships using a scalable Multiplex Serology platform in UK Biobank |
| title_short | Identification of host-pathogen-disease relationships using a scalable Multiplex Serology platform in UK Biobank |
| title_sort | identification of host pathogen disease relationships using a scalable multiplex serology platform in uk biobank |
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