Brief, irregular oscillations of basal plasma insulin and glucose concentrations in diabetic man.
The basal plasma insulin and glucose concentrations of 12 diet-treated maturity-onset diabetics were measured at minute intervals for 2 h. Brief, irregular oscillations (mean period 8.8 min) in plasma insulin were superimposed on longer term fluctuations (greater than 30 min). Time series analysis d...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1981
|
| _version_ | 1826280660784906240 |
|---|---|
| author | Lang, D Matthews, DR Burnett, M Turner, R |
| author_facet | Lang, D Matthews, DR Burnett, M Turner, R |
| author_sort | Lang, D |
| collection | OXFORD |
| description | The basal plasma insulin and glucose concentrations of 12 diet-treated maturity-onset diabetics were measured at minute intervals for 2 h. Brief, irregular oscillations (mean period 8.8 min) in plasma insulin were superimposed on longer term fluctuations (greater than 30 min). Time series analysis demonstrated a synchronous plasma glucose oscillation (mean amplitude 0.03 mmol/L) associated with short insulin cycles. The glucose changes seen in diabetic subjects were similar to the short plasma insulin cycles (less than 10 min) observed in normal subjects. In contrast, the longer plasma insulin cycles (greater than 10 min) of normal subjects were associated with a plasma glucose oscillation that rose before the end of the cycle. The demonstration of insulin oscillations independent of preceding plasma glucose changes in both normal and diabetic subjects suggests a pancreatic oscillating mechanism of "pacemaker". The associated glucose changes may reflect the entrainment, by the insulin cycles, of glucose production or utilization. |
| first_indexed | 2024-03-07T00:17:02Z |
| format | Journal article |
| id | oxford-uuid:7b354fb2-d6a6-4b8a-a7ac-8b337dcc982e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:17:02Z |
| publishDate | 1981 |
| record_format | dspace |
| spelling | oxford-uuid:7b354fb2-d6a6-4b8a-a7ac-8b337dcc982e2022-03-26T20:49:08ZBrief, irregular oscillations of basal plasma insulin and glucose concentrations in diabetic man.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7b354fb2-d6a6-4b8a-a7ac-8b337dcc982eEnglishSymplectic Elements at Oxford1981Lang, DMatthews, DRBurnett, MTurner, RThe basal plasma insulin and glucose concentrations of 12 diet-treated maturity-onset diabetics were measured at minute intervals for 2 h. Brief, irregular oscillations (mean period 8.8 min) in plasma insulin were superimposed on longer term fluctuations (greater than 30 min). Time series analysis demonstrated a synchronous plasma glucose oscillation (mean amplitude 0.03 mmol/L) associated with short insulin cycles. The glucose changes seen in diabetic subjects were similar to the short plasma insulin cycles (less than 10 min) observed in normal subjects. In contrast, the longer plasma insulin cycles (greater than 10 min) of normal subjects were associated with a plasma glucose oscillation that rose before the end of the cycle. The demonstration of insulin oscillations independent of preceding plasma glucose changes in both normal and diabetic subjects suggests a pancreatic oscillating mechanism of "pacemaker". The associated glucose changes may reflect the entrainment, by the insulin cycles, of glucose production or utilization. |
| spellingShingle | Lang, D Matthews, DR Burnett, M Turner, R Brief, irregular oscillations of basal plasma insulin and glucose concentrations in diabetic man. |
| title | Brief, irregular oscillations of basal plasma insulin and glucose concentrations in diabetic man. |
| title_full | Brief, irregular oscillations of basal plasma insulin and glucose concentrations in diabetic man. |
| title_fullStr | Brief, irregular oscillations of basal plasma insulin and glucose concentrations in diabetic man. |
| title_full_unstemmed | Brief, irregular oscillations of basal plasma insulin and glucose concentrations in diabetic man. |
| title_short | Brief, irregular oscillations of basal plasma insulin and glucose concentrations in diabetic man. |
| title_sort | brief irregular oscillations of basal plasma insulin and glucose concentrations in diabetic man |
| work_keys_str_mv | AT langd briefirregularoscillationsofbasalplasmainsulinandglucoseconcentrationsindiabeticman AT matthewsdr briefirregularoscillationsofbasalplasmainsulinandglucoseconcentrationsindiabeticman AT burnettm briefirregularoscillationsofbasalplasmainsulinandglucoseconcentrationsindiabeticman AT turnerr briefirregularoscillationsofbasalplasmainsulinandglucoseconcentrationsindiabeticman |