Mechanisms of human histone and nucleic acid demethylases.

Mechanisms of human histone and nucleic acid demethylases.

अन्य संस्करण दिखाएं (1)

The discovery that protein and nucleic acid demethylation is common opens up the possibility of 'methylation cycles' of functional importance, including in the regulation of gene expression. The mechanisms of known demethylases can be broadly divided into those involving nucleophilic catal...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Walport, L, Hopkinson, R, Schofield, C
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2012

समान संसाधन

Mechanisms of human histone and nucleic acid demethylases
द्वारा: Walport, L, और अन्य
प्रकाशित: (2012)

Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases.
द्वारा: Walport, L, और अन्य
प्रकाशित: (2016)

Human histone demethylase KDM6B can catalyse sequential oxidations
द्वारा: Hopkinson, R, और अन्य
प्रकाशित: (2018)

Recent progress in histone demethylase inhibitors
द्वारा: McAllister, T, और अन्य
प्रकाशित: (2016)

Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases
द्वारा: Louise J. Walport, और अन्य
प्रकाशित: (2016-06-01)

NMR analyses on N-hydroxymethylated nucleobases - implications for formaldehyde toxicity and nucleic acid demethylases
द्वारा: Shishodia, S, और अन्य
प्रकाशित: (2018)

Targeting histone lysine demethylases - Progress, challenges, and the future.
द्वारा: Thinnes, C, और अन्य
प्रकाशित: (2014)

Mechanistic Studies on Histone Demethylases and Related Enzymes
द्वारा: Hopkinson, R
प्रकाशित: (2013)

Structure and mechanism guided identification of histone demethylase inhibitors
द्वारा: Schofield, C
प्रकाशित: (2010)

Mechanistic studies on histone demethylases and related enzymes
द्वारा: Hopkinson, RJ
प्रकाशित: (2013)

Highly selective inhibition of histone demethylases by de novo macrocyclic peptides
द्वारा: Kawamura, A, और अन्य
प्रकाशित: (2017)

Monitoring the activity of 2-oxoglutarate dependent histone demethylases by NMR spectroscopy: direct observation of formaldehyde.
द्वारा: Hopkinson, R, और अन्य
प्रकाशित: (2010)

Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase.
द्वारा: Sánchez-Fernández, E, और अन्य
प्रकाशित: (2013)

Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase.
द्वारा: Woon, E, और अन्य
प्रकाशित: (2012)

Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase.
द्वारा: Walport, L, और अन्य
प्रकाशित: (2014)

Analysis of JmjC Demethylase-Catalyzed Demethylation Using Geometrically-Constrained Lysine Analogues
द्वारा: Langley, G, और अन्य
प्रकाशित: (2015)

Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation.
द्वारा: Aik, W, और अन्य
प्रकाशित: (2014)

Highly selective inhibition of histone demethylases by de novo macrocyclic peptides
द्वारा: Akane Kawamura, और अन्य
प्रकाशित: (2017-04-01)

Structure of human RNA N(6)-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation
द्वारा: Aik, W, और अन्य
प्रकाशित: (2014)

Kinetic investigations on the reaction of a 2-oxoglutarate dependent histone demethylase with oxygen
द्वारा: Sanchez-Fernandez, E, और अन्य
प्रकाशित: (2012)

Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities.
द्वारा: Rotili, D, और अन्य
प्रकाशित: (2014)

Conformational dynamics underlies different functions of human KDM7 histone demethylases
द्वारा: Chaturvedi, S, और अन्य
प्रकाशित: (2019)

Conformational flexibility influences structure–function relationships in nucleic acid N-methyl demethylases
द्वारा: Waheed, SO, और अन्य
प्रकाशित: (2019)

Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.
द्वारा: Rose, N, और अन्य
प्रकाशित: (2012)

Zn-ejection for the selective inhibition of JMJD2 histone demethylases
द्वारा: Sekirnik, R, और अन्य
प्रकाशित: (2012)

A miniaturized screen for inhibitors of Jumonji histone demethylases.
द्वारा: Sakurai, M, और अन्य
प्रकाशित: (2010)

A miniaturized screen for inhibitors of Jumonji histone demethylases.
द्वारा: Sakurai, M, और अन्य
प्रकाशित: (2010)

Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases
द्वारा: Bhushan, B, और अन्य
प्रकाशित: (2018)

Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.
द्वारा: Suzuki, T, और अन्य
प्रकाशित: (2013)

Histone demethylases in autophagy and inflammation
द्वारा: Yaoyao Ma, और अन्य
प्रकाशित: (2025-01-01)

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
द्वारा: Chowdhury, R, और अन्य
प्रकाशित: (2011)

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
द्वारा: Chowdhury, R, और अन्य
प्रकाशित: (2011)

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
द्वारा: Chowdhury, R, और अन्य
प्रकाशित: (2011)

Studies on the interaction of the histone demethylase KDM5B with tricarboxylic acid cycle intermediates
द्वारा: Tarhonskaya, H, और अन्य
प्रकाशित: (2017)

Development of homogeneous luminescence assays for histone demethylase catalysis and binding.
द्वारा: Kawamura, A, और अन्य
प्रकाशित: (2010)

Development of homogeneous luminescence assays for histone demethylase catalysis and binding.
द्वारा: Kawamura, A, और अन्य
प्रकाशित: (2010)

Assessing histone demethylase inhibitors in cells: lessons learned
द्वारा: Hatch, S, और अन्य
प्रकाशित: (2017)

Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.
द्वारा: Hillringhaus, L, और अन्य
प्रकाशित: (2011)

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
द्वारा: Rose, N, और अन्य
प्रकाशित: (2008)

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
द्वारा: Rose, N, और अन्य
प्रकाशित: (2008)