Mechanisms of human histone and nucleic acid demethylases.

Mechanisms of human histone and nucleic acid demethylases.

Показать другие версии (1)

The discovery that protein and nucleic acid demethylation is common opens up the possibility of 'methylation cycles' of functional importance, including in the regulation of gene expression. The mechanisms of known demethylases can be broadly divided into those involving nucleophilic catal...

Полное описание

Библиографические подробности
Главные авторы:	Walport, L, Hopkinson, R, Schofield, C
Формат:	Journal article
Язык:	English
Опубликовано:	2012

Схожие документы

Mechanisms of human histone and nucleic acid demethylases
по: Walport, L, и др.
Опубликовано: (2012)

Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases.
по: Walport, L, и др.
Опубликовано: (2016)

Human histone demethylase KDM6B can catalyse sequential oxidations
по: Hopkinson, R, и др.
Опубликовано: (2018)

Recent progress in histone demethylase inhibitors
по: McAllister, T, и др.
Опубликовано: (2016)

Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases
по: Louise J. Walport, и др.
Опубликовано: (2016-06-01)

NMR analyses on N-hydroxymethylated nucleobases - implications for formaldehyde toxicity and nucleic acid demethylases
по: Shishodia, S, и др.
Опубликовано: (2018)

Targeting histone lysine demethylases - Progress, challenges, and the future.
по: Thinnes, C, и др.
Опубликовано: (2014)

Mechanistic Studies on Histone Demethylases and Related Enzymes
по: Hopkinson, R
Опубликовано: (2013)

Structure and mechanism guided identification of histone demethylase inhibitors
по: Schofield, C
Опубликовано: (2010)

Mechanistic studies on histone demethylases and related enzymes
по: Hopkinson, RJ
Опубликовано: (2013)

Highly selective inhibition of histone demethylases by de novo macrocyclic peptides
по: Kawamura, A, и др.
Опубликовано: (2017)

Monitoring the activity of 2-oxoglutarate dependent histone demethylases by NMR spectroscopy: direct observation of formaldehyde.
по: Hopkinson, R, и др.
Опубликовано: (2010)

Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase.
по: Sánchez-Fernández, E, и др.
Опубликовано: (2013)

Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase.
по: Woon, E, и др.
Опубликовано: (2012)

Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase.
по: Walport, L, и др.
Опубликовано: (2014)

Analysis of JmjC Demethylase-Catalyzed Demethylation Using Geometrically-Constrained Lysine Analogues
по: Langley, G, и др.
Опубликовано: (2015)

Structure of human RNA N⁶-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation.
по: Aik, W, и др.
Опубликовано: (2014)

Highly selective inhibition of histone demethylases by de novo macrocyclic peptides
по: Akane Kawamura, и др.
Опубликовано: (2017-04-01)

Structure of human RNA N(6)-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation
по: Aik, W, и др.
Опубликовано: (2014)

Kinetic investigations on the reaction of a 2-oxoglutarate dependent histone demethylase with oxygen
по: Sanchez-Fernandez, E, и др.
Опубликовано: (2012)

Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities.
по: Rotili, D, и др.
Опубликовано: (2014)

Conformational dynamics underlies different functions of human KDM7 histone demethylases
по: Chaturvedi, S, и др.
Опубликовано: (2019)

Conformational flexibility influences structure–function relationships in nucleic acid N-methyl demethylases
по: Waheed, SO, и др.
Опубликовано: (2019)

Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.
по: Rose, N, и др.
Опубликовано: (2012)

Zn-ejection for the selective inhibition of JMJD2 histone demethylases
по: Sekirnik, R, и др.
Опубликовано: (2012)

A miniaturized screen for inhibitors of Jumonji histone demethylases.
по: Sakurai, M, и др.
Опубликовано: (2010)

A miniaturized screen for inhibitors of Jumonji histone demethylases.
по: Sakurai, M, и др.
Опубликовано: (2010)

Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases
по: Bhushan, B, и др.
Опубликовано: (2018)

Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.
по: Suzuki, T, и др.
Опубликовано: (2013)

Histone demethylases in autophagy and inflammation
по: Yaoyao Ma, и др.
Опубликовано: (2025-01-01)

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
по: Chowdhury, R, и др.
Опубликовано: (2011)

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
по: Chowdhury, R, и др.
Опубликовано: (2011)

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
по: Chowdhury, R, и др.
Опубликовано: (2011)

Studies on the interaction of the histone demethylase KDM5B with tricarboxylic acid cycle intermediates
по: Tarhonskaya, H, и др.
Опубликовано: (2017)

Development of homogeneous luminescence assays for histone demethylase catalysis and binding.
по: Kawamura, A, и др.
Опубликовано: (2010)

Development of homogeneous luminescence assays for histone demethylase catalysis and binding.
по: Kawamura, A, и др.
Опубликовано: (2010)

Assessing histone demethylase inhibitors in cells: lessons learned
по: Hatch, S, и др.
Опубликовано: (2017)

Structural and evolutionary basis for the dual substrate selectivity of human KDM4 histone demethylase family.
по: Hillringhaus, L, и др.
Опубликовано: (2011)

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
по: Rose, N, и др.
Опубликовано: (2008)

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
по: Rose, N, и др.
Опубликовано: (2008)