Disruption of c-MYC binding and chromosomal looping involving genetic variants associated with ankylosing spondylitis upstream of the RUNX3 promoter
<strong>Background:</strong> Ankylosing Spondylitis (AS) is a common form of inflammatory spinal arthritis with a complex aetiology and high heritability, involving more than 100 genetic associations. These include several AS-associated single nucleotide polymorphisms (SNPs) upstream of...
Autori principali: | Cohen, CJ, Davidson, C, Selmi, C, Bowness, P, Knight, JC, Wordsworth, BP, Vecellio, M |
---|---|
Natura: | Journal article |
Lingua: | English |
Pubblicazione: |
Frontiers Media
2022
|
Documenti analoghi
Documenti analoghi
-
Functional genomic analysis of a RUNX3 polymorphism associated with ankylosing spondylitis
di: Vecellio, M, et al.
Pubblicazione: (2021) -
FROM SNPs TO FUNCTION: TRANSCRIPTIONAL REGULATION OF RUNX3 IN ANKYLOSING SPONDYLITIS
di: Vecellio, M, et al.
Pubblicazione: (2014) -
Perspectives on the genetic associations of ankylosing spondylitis
di: Wordsworth, BP, et al.
Pubblicazione: (2021) -
RUNX3 and T-Bet in immunopathogenesis of ankylosing spondylitis—novel targets for therapy?
di: Vecellio, M, et al.
Pubblicazione: (2019) -
The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression
di: Vecellio, M, et al.
Pubblicazione: (2015)