An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses.
Inhibitors of the protease of HIV-1 have been used successfully for the treatment of HIV-1-infected patients and AIDS disease. We tested whether these protease inhibitory drugs exerted effects in addition to their antiviral activity. Here, we show in mice infected with lymphocytic choriomeningitis v...
المؤلفون الرئيسيون: | André, P, Groettrup, M, Klenerman, P, de Giuli, R, Booth, B, Cerundolo, V, Bonneville, M, Jotereau, F, Zinkernagel, R, Lotteau, V |
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التنسيق: | Journal article |
اللغة: | English |
منشور في: |
1998
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مواد مشابهة
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Role of the proteasome and non proteasomal proteases in the generation of CTL epitopes.
حسب: Cerundolo, V, وآخرون
منشور في: (1998) -
Effects of retroviral protease inhibitors on proteasome function and processing of HIV-derived MHC class I-restricted cytotoxic T lymphocyte epitopes.
حسب: Kelleher, A, وآخرون
منشور في: (2001) -
Generation of an immunodominant CTL epitope is affected by proteasome subunit composition and stability of the antigenic protein.
حسب: Gileadi, U, وآخرون
منشور في: (1999) -
Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes.
حسب: Klenerman, P, وآخرون
منشور في: (1998) -
The HIV Protease Inhibitor Nelfinavir Downregulates Akt Phosphorylation by Inhibiting Proteasomal Activity and Inducing the Unfolded Protein Response
حسب: Anjali K. Gupta, وآخرون
منشور في: (2007-04-01)