An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses.

An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses.

Inhibitors of the protease of HIV-1 have been used successfully for the treatment of HIV-1-infected patients and AIDS disease. We tested whether these protease inhibitory drugs exerted effects in addition to their antiviral activity. Here, we show in mice infected with lymphocytic choriomeningitis v...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	André, P, Groettrup, M, Klenerman, P, de Giuli, R, Booth, B, Cerundolo, V, Bonneville, M, Jotereau, F, Zinkernagel, R, Lotteau, V
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	1998

Eitemau Tebyg

Role of the proteasome and non proteasomal proteases in the generation of CTL epitopes.
gan: Cerundolo, V, et al.
Cyhoeddwyd: (1998)

Effects of retroviral protease inhibitors on proteasome function and processing of HIV-derived MHC class I-restricted cytotoxic T lymphocyte epitopes.
gan: Kelleher, A, et al.
Cyhoeddwyd: (2001)

Generation of an immunodominant CTL epitope is affected by proteasome subunit composition and stability of the antigenic protein.
gan: Gileadi, U, et al.
Cyhoeddwyd: (1999)

Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes.
gan: Klenerman, P, et al.
Cyhoeddwyd: (1998)

The HIV Protease Inhibitor Nelfinavir Downregulates Akt Phosphorylation by Inhibiting Proteasomal Activity and Inducing the Unfolded Protein Response
gan: Anjali K. Gupta, et al.
Cyhoeddwyd: (2007-04-01)

CD8+ T cell epitope-flanking mutations disrupt proteasomal processing of HIV-1 Nef.
gan: Milicic, A, et al.
Cyhoeddwyd: (2005)

Competitive Metabolite Profiling of Natural Products Reveals Subunit Specific Inhibitors of the 20S Proteasome
gan: Atul Pawar, et al.
Cyhoeddwyd: (2020-01-01)

Modulation of proteasomal activity required for the generation of a cytotoxic T lymphocyte-defined peptide derived from the tumor antigen MAGE-3.
gan: Valmori, D, et al.
Cyhoeddwyd: (1999)

Computational investigations of HIV-1 protease and protease inhibitors interactions
gan: Sham, Hoi Fung
Cyhoeddwyd: (2014)

The proteasome-specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells.
gan: Cerundolo, V, et al.
Cyhoeddwyd: (1997)

Current and Novel Inhibitors of HIV Protease
gan: Jan Konvalinka, et al.
Cyhoeddwyd: (2009-12-01)

Conjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 targets it for proteasomal degradation.
gan: Johanna Bialas, et al.
Cyhoeddwyd: (2015-01-01)

Alteration of HIV epitope processing and presentation by HIV protease inhibitors
gan: Kourjian G, et al.
Cyhoeddwyd: (2012-09-01)

Additivity in the Analysis and Design of HIV Protease Inhibitors
gan: Jorissen, Robert N., et al.
Cyhoeddwyd: (2012)

PRACTICE OF USING VIRAL PROTEASE INHIBITORS IN CHILDREN WITH HIV INFECTION
gan: V.B. Denisenko, et al.
Cyhoeddwyd: (2010-02-01)

PRACTICE OF USING VIRAL PROTEASE INHIBITORS IN CHILDREN WITH HIV INFECTION
gan: V.B. Denisenko, et al.
Cyhoeddwyd: (2010-02-01)

Proteasome inhibitors as anti-cancer agents.
gan: Murray, R, et al.
Cyhoeddwyd: (2000)

Optimal activation of tumor-reactive T cells by selected antigenic peptide analogues.
gan: Valmori, D, et al.
Cyhoeddwyd: (1999)

Down-regulation of Akt signaling with HIV-1 protease inhibitors
gan: Gupta, A, et al.
Cyhoeddwyd: (2005)

Effects of an anticarcinogenic Bowman-Birk protease inhibitor on purified 20S proteasome and MCF-7 breast cancer cells.
gan: Larissa da Costa Souza, et al.
Cyhoeddwyd: (2014-01-01)

New proteasome inhibitors in the management of multiple myeloma
gan: S. V. Semochkin
Cyhoeddwyd: (2019-07-01)

MAPPING OF PATENTS RELATED TO PROTEASE INHIBITORS AND HIV
gan: Romério Rodrigues dos Santos Silva, et al.
Cyhoeddwyd: (2022-04-01)

Role of Gag in HIV Resistance to Protease Inhibitors
gan: Fabrizio Mammano, et al.
Cyhoeddwyd: (2010-07-01)

Two Novel Precursors of the HIV-1 Protease Inhibitor Darunavir Target the UPR/Proteasome System in Human Hepatocellular Carcinoma Cell Line HepG2
gan: Roberta Rinaldi, et al.
Cyhoeddwyd: (2021-11-01)

TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation
gan: Abhilash I. Chiramel, et al.
Cyhoeddwyd: (2019-06-01)

Site-Specific Proteasome Inhibitors
gan: Alexei F. Kisselev
Cyhoeddwyd: (2021-12-01)

Clinical Use of Proteasome Inhibitors in the Treatment of Multiple Myeloma
gan: Noah M. Merin, et al.
Cyhoeddwyd: (2014-12-01)

Treatment with the HIV protease inhibitor nelfinavir triggers the unfolded protein response and may overcome proteasome inhibitor resistance of multiple myeloma in combination with bortezomib: a phase I trial (SAKK 65/08)
gan: Christoph Driessen, et al.
Cyhoeddwyd: (2016-03-01)

Human T-cell leukemia virus type 1 Tax protein binds to assembled nuclear proteasomes and enhances their proteolytic activity.
gan: Hemelaar, J, et al.
Cyhoeddwyd: (2001)

The capture proteasome assay (CAPA) to evaluate subtype-specific proteasome inhibitors
gan: Nathalie Vigneron, et al.
Cyhoeddwyd: (2015-09-01)

Evaluation of COVID-19 protease and HIV inhibitors interactions
gan: Tran Linh, et al.
Cyhoeddwyd: (2022-03-01)

Safety of protease inhibitors in HIV-infected pregnant women
gan: Chougrani I, et al.
Cyhoeddwyd: (2013-09-01)

Cardio-metabolic effectsof HIV protease inhibitors (lopinavir/ritonavir).
gan: Kathleen M S E Reyskens, et al.
Cyhoeddwyd: (2013-01-01)

HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat
gan: Konvalinka Jan, et al.
Cyhoeddwyd: (2011-08-01)

Evaluation of Platelet Activation by HIV Protease Inhibitors – The HIV-PLA II Study
gan: Kann G, et al.
Cyhoeddwyd: (2021-08-01)

Immune surveillance and AIDS progression.
gan: Zinkernagel, R, et al.
Cyhoeddwyd: (1997)

Correspondence - Immune surveillance and AIDS progression
gan: Zinkernagel, R, et al.
Cyhoeddwyd: (1997)

Of mice and men: cytotoxic T cells and AIDS pathogenesis.
gan: Klenerman, P, et al.
Cyhoeddwyd: (1999)

What can we learn about human immunodeficiency virus infection from a study of lymphocytic choriomeningitis virus?
gan: Klenerman, P, et al.
Cyhoeddwyd: (1997)

Resistance associated mutations to protease inhibitors on HIV-2 infected patients in Portugal
gan: J. Lopes, et al.
Cyhoeddwyd: (2021-04-01)