Synthesis of the Taxol core using asymmetric 1,4-additions

Synthesis of the Taxol core using asymmetric 1,4-additions

<p>The topic of this thesis is the synthesis of Taxane derivatives using the asymmetric conjugate addition of alkenes. Taxol is an important anti-cancer drug and owing to its complex structure, remains a subject of fascination by chemists. The asymmetric conjugate addition of alkenes is a pow...

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Bibliografiske detaljer
Hovedforfatter:	Wang, JY
Andre forfattere:	Fletcher, S
Format:	Thesis
Sprog:	English
Udgivet:	2020
Fag:	Chemistry, Organic

Lignende værker

Synthesis of the taxol core via catalytic asymmetric 1,4-addition of an Alkylzirconium Nucleophile
af: Wang, JYJ, et al.
Udgivet: (2020)

New asymmetric metal-catalysed addition processes for amine synthesis
af: Franchino, A
Udgivet: (2017)

Asymmetric conjugate additions of alkylzirconocenes to cyclopent-4-ene-1,3-dione monoacetals.
af: Rideau, E, et al.
Udgivet: (2015)

Asymmetric synthesis of the loline alkaloids
af: Linsdall, SM
Udgivet: (2019)

Streamlined synthesis of taxol analogues
af: Rodriguez, P
Udgivet: (2017)

Rapid synthesis of the Taxol core
af: Thomas, P
Udgivet: (2019)

Synthesis and biological activity of fused tetracyclic Pyrrolo[2,1-c][1,4]benzodiazepines
af: Joel K. Annor-Gyamfi, et al.
Udgivet: (2018-02-01)

Asymmetric synthesis of piperidine alkaloids
af: Thomson, A, et al.
Udgivet: (2012)

Asymmetric synthesis of amino polyols
af: Foster, E
Udgivet: (2012)

Enantiorecognition phenomena in asymmetric synthesis
af: Yin, J, et al.
Udgivet: (2011)

Enantiopure lithium amides in asymmetric synthesis
af: Lv, L
Udgivet: (2013)

Aziridines and aziridinium intermediates in the asymmetric synthesis of beta-substituted-alpha-amino acids and 1,2,3,4-tetrahydroisoquinolines
af: Frost, A
Udgivet: (2015)

Organocatalytic asymmetric mannich, formal [4+1] and [4+2] annulation reactions
af: Shi, Zugui
Udgivet: (2012)

New chiral ligands and catalysts for asymmetric synthesis
af: Xiao, Jian
Udgivet: (2010)

Applications of triazoline diones in imaging and asymmetric synthesis
af: Cai, Melody Pei Ling
Udgivet: (2010)

Asymmetric synthesis of the Martinella alkaloids
af: Lorkin, T, et al.
Udgivet: (2013)

Asymmetric synthesis of cyano- functionalised-1, 3-diphosphine via organopalladium promoted hydrophosphination reaction.
af: Lee, Zhi Yi.
Udgivet: (2010)

Asymmetric synthesis of chiral arsine ligands promoted by organopalladium complexes
af: Lim, Maricar Bungabong
Udgivet: (2009)

Asymmetric total synthesis of inthomycin c and studies towards the total synthesis of oxazolomycin b
af: Garcia, S
Udgivet: (2017)

Asymmetric synthesis of chiral phosphines and arsines promoted by organometallic complexes
af: Liu, Fengli
Udgivet: (2010)

Synthesis of the pyrrolidinone core of oxazolomycin A
af: O'Riordan, TJC
Udgivet: (2009)

Palladacycle catalyzed asymmetric P-H addition of diarylphosphines to N-enoyl phthalimides
af: Chew, Renta Jonathan, et al.
Udgivet: (2014)

Asymmetric synthesis of α-alkylated aldehydes using chiral enamines
af: Kaka, N, et al.
Udgivet: (2008)

ASYMMETRIC-SYNTHESIS OF THE TAXOL AND TAXOTERE C-13 SIDE-CHAINS
af: Bunnage, M, et al.
Udgivet: (1994)

Asymmetric synthesis of phosphines via chiral cyclopalladium(II) complexes promoted reactions
af: Yi, Zhang
Udgivet: (2011)

Development of organocatalytic asymmetric a-aminoxylation reactions: enantioselecitve synthesis of oxygenated compounds.
af: Lu, Min
Udgivet: (2014)

Cobalt-catalyzed arylzincation of alkynes and alkenes involving 1,4-cobalt migration
af: Tan, Boon Hong
Udgivet: (2015)

Synthesis and reactivities of novel divalent group 14 elements species
af: Wang, Liliang
Udgivet: (2018)

Asymmetric synthesis of heterocycles via cation-directed cyclizations and rearrangements
af: Lamb, A, et al.
Udgivet: (2014)

Synthesis of cyanolide A and the neopeltolide core structure
af: Lek, Tee Guan
Udgivet: (2016)

Synthesis of (−)-cytisine using a 6-endo aza-Michael addition
af: Barát, Viktor, et al.
Udgivet: (2019)

Rhodium-catalyzed 1,4-addition of triorgano(vinyl)silanes to electron-deficient olefins and application towards the preparation of functionalized organoboron compounds
af: Ng, Yu Rui
Udgivet: (2010)

Organocatalytic asymmetric 1,3-dipolarand formal 1,3-dipolar cycloaddition reactions.
af: Wang, Fei
Udgivet: (2014)

Asymmetric synthesis of functionalized chiral diphosphines via organopalladium promoted hydrophosphination and diels-alder reactions
af: Yuan, Mingjun
Udgivet: (2011)

Organocatalytic asymmetric Mannich reactions of 5H-oxazol-4-ones : highly enantio- and diastereoselective synthesis of chiral α-alkylisoserine derivatives
af: Han, Zhiqiang, et al.
Udgivet: (2014)

Synthesis of natural products by intramolecular Michael addition
af: Song, Ping
Udgivet: (2010)

Sequential michael addition/cyclisation : synthesis of multi-substituted naphthalenes.
af: Wang, Stephanie Qiu Mei.
Udgivet: (2010)

Part I: Bioinspired reactions in the synthesis of complex molecules. Part II: New generation of In(III)-pybox complex in asymmetric synthesis
af: Zhao, Junfeng
Udgivet: (2011)

Development of new carbon-carbon bond forming reactions through 1,4-migration of rhodium
af: Ming, Jialin
Udgivet: (2018)

Development of phosphapalladacycles as potential catalysts for asymmetric synthesis
af: Chiew, Jun Xuan
Udgivet: (2017)