Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles.
Experimental evidence implicates tumor necrosis factor (TNF) in the pathogenesis of malarial anemia, but there are few data relating to this hypothesis. This study found that severely anemic children with Plasmodium falciparum infection have low plasma TNF levels, in contrast to the high levels foun...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1999
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| _version_ | 1797077428061863936 |
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| author | McGuire, W Knight, J Hill, A Allsopp, C Greenwood, B Kwiatkowski, D |
| author_facet | McGuire, W Knight, J Hill, A Allsopp, C Greenwood, B Kwiatkowski, D |
| author_sort | McGuire, W |
| collection | OXFORD |
| description | Experimental evidence implicates tumor necrosis factor (TNF) in the pathogenesis of malarial anemia, but there are few data relating to this hypothesis. This study found that severely anemic children with Plasmodium falciparum infection have low plasma TNF levels, in contrast to the high levels found in cerebral malaria. A previous case-control study in The Gambia found cerebral malaria, but not severe malarial anemia, was associated with the TNF-308 A allele. This study found that in the same population, severe malarial anemia was associated with the TNF-238 A allele, with an odds ratio of 2.5 (P<.001) after stratification for HLA type. These findings suggest that severe malarial anemia and cerebral malaria are influenced by separate genetic factors situated near the TNF gene. |
| first_indexed | 2024-03-07T00:17:50Z |
| format | Journal article |
| id | oxford-uuid:7b77e9fe-8846-42ba-b1ad-6217518f3e06 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:17:50Z |
| publishDate | 1999 |
| record_format | dspace |
| spelling | oxford-uuid:7b77e9fe-8846-42ba-b1ad-6217518f3e062022-03-26T20:50:46ZSevere malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7b77e9fe-8846-42ba-b1ad-6217518f3e06EnglishSymplectic Elements at Oxford1999McGuire, WKnight, JHill, AAllsopp, CGreenwood, BKwiatkowski, DExperimental evidence implicates tumor necrosis factor (TNF) in the pathogenesis of malarial anemia, but there are few data relating to this hypothesis. This study found that severely anemic children with Plasmodium falciparum infection have low plasma TNF levels, in contrast to the high levels found in cerebral malaria. A previous case-control study in The Gambia found cerebral malaria, but not severe malarial anemia, was associated with the TNF-308 A allele. This study found that in the same population, severe malarial anemia was associated with the TNF-238 A allele, with an odds ratio of 2.5 (P<.001) after stratification for HLA type. These findings suggest that severe malarial anemia and cerebral malaria are influenced by separate genetic factors situated near the TNF gene. |
| spellingShingle | McGuire, W Knight, J Hill, A Allsopp, C Greenwood, B Kwiatkowski, D Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles. |
| title | Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles. |
| title_full | Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles. |
| title_fullStr | Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles. |
| title_full_unstemmed | Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles. |
| title_short | Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles. |
| title_sort | severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles |
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