Quality control of ER membrane proteins by the RNF185/Membralin ubiquitin ligase complex

Misfolded proteins in the endoplasmic reticulum (ER) are degraded by ER-associated degradation (ERAD). Although ERAD components involved in degradation of luminal substrates are well characterized, much less is known about quality control of membrane proteins. Here, we analyzed the degradation pathw...

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Detalles Bibliográficos
Autores principales: van de Weijer, ML, Krshnan, L, Liberatori, S, Guerrero, EN, Robson-Tull, J, Hahn, L, Lebbink, RJ, Wiertz, EJHJ, Fischer, R, Ebner, D, Carvalho, P
Formato: Journal article
Lenguaje:English
Publicado: Cell Press 2020