Absence of neuronal autoantibodies in neuropsychiatric systemic lupus erythematosus
This study aimed to characterise both neuronal autoantibodies and levels of interferon α, two proposed causative agents in neuropsychiatric systemic lupus erythematosus (NPSLE). Cerebrospinal fluid (CSF) and plasma from 35 patients with systemic lupus erythematosus (SLE; 15 with NPSLE) showed no ant...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Wiley
2020
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| _version_ | 1797077432834981888 |
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| author | Varley, JA Andersson, M Grant, E Berretta, A Zandi, MS Bondet, V Duffy, D Hunt, D Piehl, F Waters, P Irani, SR |
| author_facet | Varley, JA Andersson, M Grant, E Berretta, A Zandi, MS Bondet, V Duffy, D Hunt, D Piehl, F Waters, P Irani, SR |
| author_sort | Varley, JA |
| collection | OXFORD |
| description | This study aimed to characterise both neuronal autoantibodies and levels of interferon α, two proposed causative agents in neuropsychiatric systemic lupus erythematosus (NPSLE). Cerebrospinal fluid (CSF) and plasma from 35 patients with systemic lupus erythematosus (SLE; 15 with NPSLE) showed no antibodies against natively expressed N‐methyl‐D‐aspartate receptors (NMDARs), or the surface of live hippocampal neurons. By comparison to controls (n = 104), patients with SLE had antibodies that bound to a peptide representing the extracellular domain of NMDARs (p < 0.0001), however, binding was retained against both rearranged peptides and no peptide (r = 0.85 and r = 0.79, respectively, p < 0.0001). In summary, neuronal‐surface reactive antibodies were not detected in NPSLE. Further, while interferon α levels were higher in SLE (p < 0.0001), they lacked specificity for NPSLE. Our findings mandate a search for novel biomarkers in this condition. ANN NEUROL 2020
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| first_indexed | 2024-03-07T00:17:55Z |
| format | Journal article |
| id | oxford-uuid:7b7e17b0-8fc0-4c98-8f54-e3b6169e6e3b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:17:55Z |
| publishDate | 2020 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:7b7e17b0-8fc0-4c98-8f54-e3b6169e6e3b2022-03-26T20:51:03ZAbsence of neuronal autoantibodies in neuropsychiatric systemic lupus erythematosusJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7b7e17b0-8fc0-4c98-8f54-e3b6169e6e3bEnglishSymplectic ElementsWiley2020Varley, JAAndersson, MGrant, EBerretta, AZandi, MSBondet, VDuffy, DHunt, DPiehl, FWaters, PIrani, SRThis study aimed to characterise both neuronal autoantibodies and levels of interferon α, two proposed causative agents in neuropsychiatric systemic lupus erythematosus (NPSLE). Cerebrospinal fluid (CSF) and plasma from 35 patients with systemic lupus erythematosus (SLE; 15 with NPSLE) showed no antibodies against natively expressed N‐methyl‐D‐aspartate receptors (NMDARs), or the surface of live hippocampal neurons. By comparison to controls (n = 104), patients with SLE had antibodies that bound to a peptide representing the extracellular domain of NMDARs (p < 0.0001), however, binding was retained against both rearranged peptides and no peptide (r = 0.85 and r = 0.79, respectively, p < 0.0001). In summary, neuronal‐surface reactive antibodies were not detected in NPSLE. Further, while interferon α levels were higher in SLE (p < 0.0001), they lacked specificity for NPSLE. Our findings mandate a search for novel biomarkers in this condition. ANN NEUROL 2020 |
| spellingShingle | Varley, JA Andersson, M Grant, E Berretta, A Zandi, MS Bondet, V Duffy, D Hunt, D Piehl, F Waters, P Irani, SR Absence of neuronal autoantibodies in neuropsychiatric systemic lupus erythematosus |
| title | Absence of neuronal autoantibodies in neuropsychiatric systemic lupus erythematosus |
| title_full | Absence of neuronal autoantibodies in neuropsychiatric systemic lupus erythematosus |
| title_fullStr | Absence of neuronal autoantibodies in neuropsychiatric systemic lupus erythematosus |
| title_full_unstemmed | Absence of neuronal autoantibodies in neuropsychiatric systemic lupus erythematosus |
| title_short | Absence of neuronal autoantibodies in neuropsychiatric systemic lupus erythematosus |
| title_sort | absence of neuronal autoantibodies in neuropsychiatric systemic lupus erythematosus |
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