Rheumatoid arthritis association at 6q23.

Rheumatoid arthritis association at 6q23.

The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5) - 5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 x 10(-8)) in a validation study, as described...

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Hlavní autoři: Thomson, W, Barton, A, Ke, X, Eyre, S, Hinks, A, Bowes, J, Donn, R, Symmons, D, Hider, S, Bruce, I, Wilson, A, Marinou, I, Morgan, A, Emery, P, Carter, A, Steer, S, Hocking, L, Reid, D, Wordsworth, P, Harrison, P, Strachan, D, Worthington, J
Médium: Journal article
Jazyk:English
Vydáno: 2007
Popis
Shrnutí:The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5) - 5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 (TNFAIP3).

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