Rheumatoid arthritis association at 6q23.

Rheumatoid arthritis association at 6q23.

The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5) - 5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 x 10(-8)) in a validation study, as described...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Thomson, W, Barton, A, Ke, X, Eyre, S, Hinks, A, Bowes, J, Donn, R, Symmons, D, Hider, S, Bruce, I, Wilson, A, Marinou, I, Morgan, A, Emery, P, Carter, A, Steer, S, Hocking, L, Reid, D, Wordsworth, P, Harrison, P, Strachan, D, Worthington, J
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2007

समान संसाधन

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No evidence for association of the KLF12 gene with rheumatoid arthritis in a large UK cohort.
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Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes.
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Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.
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Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23 (vol 18, pg 2693, 2009)
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Investigating the viability of genetic screening/testing for RA susceptibility using combinations of five confirmed risk loci.
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Reevaluation of the interaction between HLA-DRB1 shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK Caucasian population.
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Predicting the risk of rheumatoid arthritis and its age of onset through modelling genetic risk variants with smoking
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Reevaluation of the Interaction Between HLA-DRB1 Shared Epitope Alleles, PTPN22, and Smoking in Determining Susceptibility to Autoantibody-Positive and Autoantibody-Negative Rheumatoid Arthritis in a Large UK Caucasian Population (vol 60, pg 2565, 2009)
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A replication study of the UK rheumatoid arthritis whole genome screen.
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द्वारा: Eyre, S, और अन्य
प्रकाशित: (2004)

Investigation of rheumatoid arthritis susceptibility loci in juvenile idiopathic arthritis confirms high degree of overlap.
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Rare variation at the TNFAIP3 locus and susceptibility to rheumatoid arthritis.
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Rare variation at the TNFAIP3 locus and susceptibility to rheumatoid arthritis
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Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis.
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REFINEMENT OF THE CRH HAPLOTYPE IN RHEUMATOID ARTHRITIS
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Linkage analysis of potential rheumatoid arthritis non-HLA susceptibility loci.
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STRATIFICATION ANALYSIS REVEALS EVIDENCE FOR LINKAGE IN SUBSETS OF 378 RA ASP FAMILIES
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Whole-genome linkage analysis of rheumatoid arthritis susceptibility loci in 252 affected sibling pairs in the United Kingdom.
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Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.
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