The influence of dietary fatty acids on liver fat content and metabolism

Non-alcoholic fatty liver disease encompasses a spectrum of conditions from hepatic steatosis through to cirrhosis; obesity is a known risk factor. The liver plays a major role in regulating fatty acid metabolism and perturbations in intrahepatic processes have potential to impact on metabolic healt...

Ամբողջական նկարագրություն

Մատենագիտական մանրամասներ
Հիմնական հեղինակներ: Hodson, L, Rosqvist, F, Parry, SA
Ձևաչափ: Journal article
Լեզու:English
Հրապարակվել է: Cambridge University Press 2019
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author Hodson, L
Rosqvist, F
Parry, SA
author_facet Hodson, L
Rosqvist, F
Parry, SA
author_sort Hodson, L
collection OXFORD
description Non-alcoholic fatty liver disease encompasses a spectrum of conditions from hepatic steatosis through to cirrhosis; obesity is a known risk factor. The liver plays a major role in regulating fatty acid metabolism and perturbations in intrahepatic processes have potential to impact on metabolic health. It remains unclear why intra-hepatocellular fat starts to accumulate, but it likely involves an imbalance between fatty acid delivery to the liver, fatty acid synthesis and oxidation within the liver and TAG export from the liver. As man spends the majority of the day in a postprandial rather than postabsorptive state, dietary fatty acid intake should be taken into consideration when investigating why intra-hepatic fat starts to accumulate. This review will discuss the impact of the quantity and quality of dietary fatty acids on liver fat accumulation and metabolism, along with some of the potential mechanisms involved. Studies investigating the role of dietary fat in liver fat accumulation, although surprisingly limited, have clearly demonstrated that it is total energy intake, rather than fat intake per se, that is a key mediator of liver fat content; hyperenergetic diets increase liver fat whilst hypoenergetic diets decrease liver fat content irrespective of total fat content. Moreover, there is now, albeit limited evidence emerging to suggest the composition of dietary fat may also play a role in liver fat accumulation, with diets enriched in saturated fat appearing to increase liver fat content to a greater extent when compared with diets enriched in unsaturated fats.
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spelling oxford-uuid:7b95af14-d71c-46f5-8e02-2bf0d0b65a842024-03-13T09:36:30ZThe influence of dietary fatty acids on liver fat content and metabolismJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7b95af14-d71c-46f5-8e02-2bf0d0b65a84EnglishSymplectic Elements at OxfordCambridge University Press2019Hodson, LRosqvist, FParry, SANon-alcoholic fatty liver disease encompasses a spectrum of conditions from hepatic steatosis through to cirrhosis; obesity is a known risk factor. The liver plays a major role in regulating fatty acid metabolism and perturbations in intrahepatic processes have potential to impact on metabolic health. It remains unclear why intra-hepatocellular fat starts to accumulate, but it likely involves an imbalance between fatty acid delivery to the liver, fatty acid synthesis and oxidation within the liver and TAG export from the liver. As man spends the majority of the day in a postprandial rather than postabsorptive state, dietary fatty acid intake should be taken into consideration when investigating why intra-hepatic fat starts to accumulate. This review will discuss the impact of the quantity and quality of dietary fatty acids on liver fat accumulation and metabolism, along with some of the potential mechanisms involved. Studies investigating the role of dietary fat in liver fat accumulation, although surprisingly limited, have clearly demonstrated that it is total energy intake, rather than fat intake per se, that is a key mediator of liver fat content; hyperenergetic diets increase liver fat whilst hypoenergetic diets decrease liver fat content irrespective of total fat content. Moreover, there is now, albeit limited evidence emerging to suggest the composition of dietary fat may also play a role in liver fat accumulation, with diets enriched in saturated fat appearing to increase liver fat content to a greater extent when compared with diets enriched in unsaturated fats.
spellingShingle Hodson, L
Rosqvist, F
Parry, SA
The influence of dietary fatty acids on liver fat content and metabolism
title The influence of dietary fatty acids on liver fat content and metabolism
title_full The influence of dietary fatty acids on liver fat content and metabolism
title_fullStr The influence of dietary fatty acids on liver fat content and metabolism
title_full_unstemmed The influence of dietary fatty acids on liver fat content and metabolism
title_short The influence of dietary fatty acids on liver fat content and metabolism
title_sort influence of dietary fatty acids on liver fat content and metabolism
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