Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia.
Therapy-related acute myeloid leukemia (t-AML) in most cases develops after chemotherapy of other malignancies and shows characteristic chromosome aberrations. Two general types of t-AML have previously been identified. One type is observed after therapy with alkylating agents and characteristically...
| Hoofdauteurs: | , , , |
|---|---|
| Formaat: | Journal article |
| Taal: | English |
| Gepubliceerd in: |
2002
|
| _version_ | 1826280738806300672 |
|---|---|
| author | Pedersen-Bjergaard, J Andersen, M Christiansen, D Nerlov, C |
| author_facet | Pedersen-Bjergaard, J Andersen, M Christiansen, D Nerlov, C |
| author_sort | Pedersen-Bjergaard, J |
| collection | OXFORD |
| description | Therapy-related acute myeloid leukemia (t-AML) in most cases develops after chemotherapy of other malignancies and shows characteristic chromosome aberrations. Two general types of t-AML have previously been identified. One type is observed after therapy with alkylating agents and characteristically presents as therapy-related myelodysplasia with deletions or loss of the long arms of chromosomes 5 and 7 or loss of the whole chromosomes. The other type is observed after therapy with topoisomerase II inhibitors and characteristically presents as overt t-AML with recurrent balanced chromosome aberrations. Recent research suggests that these 2 general types of t-AML can now be subdivided into at least 8 genetic pathways with a different etiology and different biologic characteristics. |
| first_indexed | 2024-03-07T00:18:13Z |
| format | Journal article |
| id | oxford-uuid:7b97e1d6-3cdb-4157-b2fb-1420ea6de605 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:18:13Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:7b97e1d6-3cdb-4157-b2fb-1420ea6de6052022-03-26T20:51:40ZGenetic pathways in therapy-related myelodysplasia and acute myeloid leukemia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7b97e1d6-3cdb-4157-b2fb-1420ea6de605EnglishSymplectic Elements at Oxford2002Pedersen-Bjergaard, JAndersen, MChristiansen, DNerlov, CTherapy-related acute myeloid leukemia (t-AML) in most cases develops after chemotherapy of other malignancies and shows characteristic chromosome aberrations. Two general types of t-AML have previously been identified. One type is observed after therapy with alkylating agents and characteristically presents as therapy-related myelodysplasia with deletions or loss of the long arms of chromosomes 5 and 7 or loss of the whole chromosomes. The other type is observed after therapy with topoisomerase II inhibitors and characteristically presents as overt t-AML with recurrent balanced chromosome aberrations. Recent research suggests that these 2 general types of t-AML can now be subdivided into at least 8 genetic pathways with a different etiology and different biologic characteristics. |
| spellingShingle | Pedersen-Bjergaard, J Andersen, M Christiansen, D Nerlov, C Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia. |
| title | Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia. |
| title_full | Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia. |
| title_fullStr | Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia. |
| title_full_unstemmed | Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia. |
| title_short | Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia. |
| title_sort | genetic pathways in therapy related myelodysplasia and acute myeloid leukemia |
| work_keys_str_mv | AT pedersenbjergaardj geneticpathwaysintherapyrelatedmyelodysplasiaandacutemyeloidleukemia AT andersenm geneticpathwaysintherapyrelatedmyelodysplasiaandacutemyeloidleukemia AT christiansend geneticpathwaysintherapyrelatedmyelodysplasiaandacutemyeloidleukemia AT nerlovc geneticpathwaysintherapyrelatedmyelodysplasiaandacutemyeloidleukemia |