Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.

The emerging notion of environment-induced reprogramming of Foxp3(+) regulatory T (Treg) cells into helper T (Th) cells remains controversial. By genetic fate mapping or adoptive transfers, we have identified a minor population of nonregulatory Foxp3(+) T cells exhibiting promiscuous and transient F...

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Hlavní autoři: Miyao, T, Floess, S, Setoguchi, R, Luche, H, Fehling, H, Waldmann, H, Huehn, J, Hori, S
Médium: Journal article
Jazyk:English
Vydáno: 2012