Seroprevalence of SARS-CoV-2 infection in the Colombo Municipality region, Sri Lanka
<p><strong>Background:</strong> As the Municipality Council area in Colombo (CMC) experienced the highest number of cases until the end of January 2021, in Sri Lanka, we carried out a serosurvey prior to initiation of the vaccination program to understand the extent of the SARS-CoV...
| المؤلفون الرئيسيون: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| التنسيق: | Journal article |
| اللغة: | English |
| منشور في: |
Frontiers Media
2021
|
| _version_ | 1826310916010934272 |
|---|---|
| author | Jeewandara, C Guruge, D Abyrathna, IS Danasekara, S Gunasekera, B Pushpakumara, PD Madhusanka, D Jayathilaka, D Ranasinghe, T Somathilake, G Tanussiya, S Jayadas, TT Kuruppu, H Thashmi, N Harvie, M Wijayamuni, R Schimanski, L Tan, TK Rijal, P Xiao, J Ogg, GS Townsend, A Malavige, GN |
| author_facet | Jeewandara, C Guruge, D Abyrathna, IS Danasekara, S Gunasekera, B Pushpakumara, PD Madhusanka, D Jayathilaka, D Ranasinghe, T Somathilake, G Tanussiya, S Jayadas, TT Kuruppu, H Thashmi, N Harvie, M Wijayamuni, R Schimanski, L Tan, TK Rijal, P Xiao, J Ogg, GS Townsend, A Malavige, GN |
| author_sort | Jeewandara, C |
| collection | OXFORD |
| description | <p><strong>Background:</strong> As the Municipality Council area in Colombo (CMC) experienced the highest number of cases until the end of January 2021, in Sri Lanka, we carried out a serosurvey prior to initiation of the vaccination program to understand the extent of the SARS-CoV-2 outbreak.</p>
<p><strong>Methods:</strong> SARS-CoV-2 seropositivity was determined in 2,547 individuals between the ages of 10–86 years, by the Wantai total antibody ELISA. We also compared seroprevalence using the haemagglutination test (HAT) to evaluate its usefulness in carrying out serosurveys.</p>
<p><strong>Results:</strong> The overall seropositivity rate was 24.46%, while seropositivity by HAT was 18.90%. Although The SARS-CoV-2 infection detection rates by PCR were highest in the population between the ages of 20–60 years of age, there was no statistically significant difference in the seropositivity rates in different age groups. For instance, although the seropositivity rate was highest in the 10–20 age group (34.03%), the PCR positivity rate was 9.80%. Differences in the PCR positivity rates and seropositivity rates were also seen in 60–70-year-olds (8.90 vs. 30.4%) and in individuals >70 years (4.10 vs. 1.20%). The seropositivity rate of the females was 29.70% (290/976), which was significantly higher (p < 0.002) than in males 21.2% (333/1,571).</p>
<p><strong>Conclusions:</strong> A high seroprevalence rate (24.5%) was seen in all age groups in the CMC suggesting that a high level of transmission was seen during this time. The higher PCR positivity rates between the ages of 20–60 are likely to be due to increased testing carried out in the working population. Therefore, the PCR positivity rates, appear to underestimate the true extent of the outbreak and the age groups which were infected.</p> |
| first_indexed | 2024-03-07T08:00:34Z |
| format | Journal article |
| id | oxford-uuid:7bb3312b-79db-4add-b946-c0f77001f76e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:00:34Z |
| publishDate | 2021 |
| publisher | Frontiers Media |
| record_format | dspace |
| spelling | oxford-uuid:7bb3312b-79db-4add-b946-c0f77001f76e2023-09-26T15:52:19ZSeroprevalence of SARS-CoV-2 infection in the Colombo Municipality region, Sri LankaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7bb3312b-79db-4add-b946-c0f77001f76eEnglishSymplectic ElementsFrontiers Media2021Jeewandara, CGuruge, DAbyrathna, ISDanasekara, SGunasekera, BPushpakumara, PDMadhusanka, DJayathilaka, DRanasinghe, TSomathilake, GTanussiya, SJayadas, TTKuruppu, HThashmi, NHarvie, MWijayamuni, RSchimanski, LTan, TKRijal, PXiao, JOgg, GSTownsend, AMalavige, GN<p><strong>Background:</strong> As the Municipality Council area in Colombo (CMC) experienced the highest number of cases until the end of January 2021, in Sri Lanka, we carried out a serosurvey prior to initiation of the vaccination program to understand the extent of the SARS-CoV-2 outbreak.</p> <p><strong>Methods:</strong> SARS-CoV-2 seropositivity was determined in 2,547 individuals between the ages of 10–86 years, by the Wantai total antibody ELISA. We also compared seroprevalence using the haemagglutination test (HAT) to evaluate its usefulness in carrying out serosurveys.</p> <p><strong>Results:</strong> The overall seropositivity rate was 24.46%, while seropositivity by HAT was 18.90%. Although The SARS-CoV-2 infection detection rates by PCR were highest in the population between the ages of 20–60 years of age, there was no statistically significant difference in the seropositivity rates in different age groups. For instance, although the seropositivity rate was highest in the 10–20 age group (34.03%), the PCR positivity rate was 9.80%. Differences in the PCR positivity rates and seropositivity rates were also seen in 60–70-year-olds (8.90 vs. 30.4%) and in individuals >70 years (4.10 vs. 1.20%). The seropositivity rate of the females was 29.70% (290/976), which was significantly higher (p < 0.002) than in males 21.2% (333/1,571).</p> <p><strong>Conclusions:</strong> A high seroprevalence rate (24.5%) was seen in all age groups in the CMC suggesting that a high level of transmission was seen during this time. The higher PCR positivity rates between the ages of 20–60 are likely to be due to increased testing carried out in the working population. Therefore, the PCR positivity rates, appear to underestimate the true extent of the outbreak and the age groups which were infected.</p> |
| spellingShingle | Jeewandara, C Guruge, D Abyrathna, IS Danasekara, S Gunasekera, B Pushpakumara, PD Madhusanka, D Jayathilaka, D Ranasinghe, T Somathilake, G Tanussiya, S Jayadas, TT Kuruppu, H Thashmi, N Harvie, M Wijayamuni, R Schimanski, L Tan, TK Rijal, P Xiao, J Ogg, GS Townsend, A Malavige, GN Seroprevalence of SARS-CoV-2 infection in the Colombo Municipality region, Sri Lanka |
| title | Seroprevalence of SARS-CoV-2 infection in the Colombo Municipality region, Sri Lanka |
| title_full | Seroprevalence of SARS-CoV-2 infection in the Colombo Municipality region, Sri Lanka |
| title_fullStr | Seroprevalence of SARS-CoV-2 infection in the Colombo Municipality region, Sri Lanka |
| title_full_unstemmed | Seroprevalence of SARS-CoV-2 infection in the Colombo Municipality region, Sri Lanka |
| title_short | Seroprevalence of SARS-CoV-2 infection in the Colombo Municipality region, Sri Lanka |
| title_sort | seroprevalence of sars cov 2 infection in the colombo municipality region sri lanka |
| work_keys_str_mv | AT jeewandarac seroprevalenceofsarscov2infectioninthecolombomunicipalityregionsrilanka AT guruged seroprevalenceofsarscov2infectioninthecolombomunicipalityregionsrilanka AT abyrathnais seroprevalenceofsarscov2infectioninthecolombomunicipalityregionsrilanka AT danasekaras seroprevalenceofsarscov2infectioninthecolombomunicipalityregionsrilanka AT gunasekerab seroprevalenceofsarscov2infectioninthecolombomunicipalityregionsrilanka AT pushpakumarapd seroprevalenceofsarscov2infectioninthecolombomunicipalityregionsrilanka AT madhusankad seroprevalenceofsarscov2infectioninthecolombomunicipalityregionsrilanka AT jayathilakad seroprevalenceofsarscov2infectioninthecolombomunicipalityregionsrilanka AT ranasinghet seroprevalenceofsarscov2infectioninthecolombomunicipalityregionsrilanka AT somathilakeg seroprevalenceofsarscov2infectioninthecolombomunicipalityregionsrilanka AT tanussiyas seroprevalenceofsarscov2infectioninthecolombomunicipalityregionsrilanka AT jayadastt seroprevalenceofsarscov2infectioninthecolombomunicipalityregionsrilanka AT kuruppuh seroprevalenceofsarscov2infectioninthecolombomunicipalityregionsrilanka AT thashmin seroprevalenceofsarscov2infectioninthecolombomunicipalityregionsrilanka AT harviem seroprevalenceofsarscov2infectioninthecolombomunicipalityregionsrilanka AT wijayamunir seroprevalenceofsarscov2infectioninthecolombomunicipalityregionsrilanka AT schimanskil seroprevalenceofsarscov2infectioninthecolombomunicipalityregionsrilanka AT tantk seroprevalenceofsarscov2infectioninthecolombomunicipalityregionsrilanka AT rijalp seroprevalenceofsarscov2infectioninthecolombomunicipalityregionsrilanka AT xiaoj seroprevalenceofsarscov2infectioninthecolombomunicipalityregionsrilanka AT ogggs seroprevalenceofsarscov2infectioninthecolombomunicipalityregionsrilanka AT townsenda seroprevalenceofsarscov2infectioninthecolombomunicipalityregionsrilanka AT malavigegn seroprevalenceofsarscov2infectioninthecolombomunicipalityregionsrilanka |