Dynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin
<p>Growing evidence from the dynamical analysis of functional neuroimaging data suggests that brain function can be understood as the exploration of a repertoire of metastable connectivity patterns (‘functional brain networks’), which potentially underlie different mental processes.</p>...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2019
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| _version_ | 1797077493806530560 |
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| author | Lord, L-D Expert, P Atasoy, S Roseman, L Rapuano, K Lambiotte, R Nutt, DJ Deco, G Carhart-Harris, RL Kringelbach, ML Cabral, J |
| author_facet | Lord, L-D Expert, P Atasoy, S Roseman, L Rapuano, K Lambiotte, R Nutt, DJ Deco, G Carhart-Harris, RL Kringelbach, ML Cabral, J |
| author_sort | Lord, L-D |
| collection | OXFORD |
| description | <p>Growing evidence from the dynamical analysis of functional neuroimaging data suggests that brain function can be understood as the exploration of a repertoire of metastable connectivity patterns (‘functional brain networks’), which potentially underlie different mental processes.</p>
<p>The present study characterizes how the brain's dynamical exploration of resting-state networks is rapidly modulated by intravenous infusion of psilocybin, a tryptamine psychedelic found in “magic mushrooms”. We employed a data-driven approach to characterize recurrent functional connectivity patterns by focusing on the leading eigenvector of BOLD phase coherence at single-TR resolution. Recurrent BOLD phase-locking patterns (PL states) were assessed and statistically compared pre- and post-infusion of psilocybin in terms of their probability of occurrence and transition profiles. Results were validated using a placebo session.</p>
<p>Recurrent BOLD PL states revealed high spatial overlap with canonical resting-state networks. Notably, a PL state forming a frontoparietal subsystem was strongly destabilized after psilocybin injection, with a concomitant increase in the probability of occurrence of another PL state characterized by global BOLD phase coherence. These findings provide evidence of network-specific neuromodulation by psilocybin and represent one of the first attempts at bridging molecular pharmacodynamics and whole-brain network dynamics.</p> |
| first_indexed | 2024-03-07T00:18:51Z |
| format | Journal article |
| id | oxford-uuid:7bd266a9-7651-4941-a041-461bbc2a9bd7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:18:51Z |
| publishDate | 2019 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:7bd266a9-7651-4941-a041-461bbc2a9bd72022-03-26T20:53:00ZDynamical exploration of the repertoire of brain networks at rest is modulated by psilocybinJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7bd266a9-7651-4941-a041-461bbc2a9bd7EnglishSymplectic Elements at OxfordElsevier2019Lord, L-DExpert, PAtasoy, SRoseman, LRapuano, KLambiotte, RNutt, DJDeco, GCarhart-Harris, RLKringelbach, MLCabral, J<p>Growing evidence from the dynamical analysis of functional neuroimaging data suggests that brain function can be understood as the exploration of a repertoire of metastable connectivity patterns (‘functional brain networks’), which potentially underlie different mental processes.</p> <p>The present study characterizes how the brain's dynamical exploration of resting-state networks is rapidly modulated by intravenous infusion of psilocybin, a tryptamine psychedelic found in “magic mushrooms”. We employed a data-driven approach to characterize recurrent functional connectivity patterns by focusing on the leading eigenvector of BOLD phase coherence at single-TR resolution. Recurrent BOLD phase-locking patterns (PL states) were assessed and statistically compared pre- and post-infusion of psilocybin in terms of their probability of occurrence and transition profiles. Results were validated using a placebo session.</p> <p>Recurrent BOLD PL states revealed high spatial overlap with canonical resting-state networks. Notably, a PL state forming a frontoparietal subsystem was strongly destabilized after psilocybin injection, with a concomitant increase in the probability of occurrence of another PL state characterized by global BOLD phase coherence. These findings provide evidence of network-specific neuromodulation by psilocybin and represent one of the first attempts at bridging molecular pharmacodynamics and whole-brain network dynamics.</p> |
| spellingShingle | Lord, L-D Expert, P Atasoy, S Roseman, L Rapuano, K Lambiotte, R Nutt, DJ Deco, G Carhart-Harris, RL Kringelbach, ML Cabral, J Dynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin |
| title | Dynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin |
| title_full | Dynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin |
| title_fullStr | Dynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin |
| title_full_unstemmed | Dynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin |
| title_short | Dynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin |
| title_sort | dynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin |
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