Type 2 diabetes risk alleles are associated with reduced size at birth.

Type 2 diabetes risk alleles are associated with reduced size at birth.

OBJECTIVE: Low birth weight is associated with an increased risk of type 2 diabetes. The mechanisms underlying this association are unknown and may represent intrauterine programming or two phenotypes of one genotype. The fetal insulin hypothesis proposes that common genetic variants that reduce ins...

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Príomhchruthaitheoirí:	Freathy, R, Bennett, A, Ring, S, Shields, B, Groves, C, Timpson, N, Weedon, M, Zeggini, E, Lindgren, C, Lango, H, Perry, JR, Pouta, A, Ruokonen, A, Hyppönen, E, Power, C, Elliott, P, Strachan, D, Järvelin, MR, Smith, G, McCarthy, M, Frayling, T, Hattersley, A
Formáid:	Conference item
Foilsithe / Cruthaithe:	2009

Míreanna comhchosúla

Direct evidence to support the fetal insulin hypothesis as the type 2 diabetes risk alleles at the CDKALI and HHEX-IDE gene loci reduce birth weight
de réir: Hattersley, A, et al.
Foilsithe / Cruthaithe: (2008)

Common variation in the FTO (fused toes) gene is strongly associated with adiposity measures in the northern finnish birth cohort of 1966
de réir: Bennett, A, et al.
Foilsithe / Cruthaithe: (2007)

Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.
de réir: Freathy, R, et al.
Foilsithe / Cruthaithe: (2007)

Biological pathway analysis for type 2 diabetes using genome-wide association data
de réir: Weedon, M, et al.
Foilsithe / Cruthaithe: (2007)

Type 2 diabetes transcription factor 7-like 2 (TCF7L2) risk alleles reduce beta-cell function and increase birth weight
de réir: Freathy, R, et al.
Foilsithe / Cruthaithe: (2007)

Large-scale replication typing of modest signals from genome-wide association studies identifies additional type 2 diabetes susceptibility variants in the IGF2BP2 and VEGFA genes
de réir: Zeggini, E, et al.
Foilsithe / Cruthaithe: (2007)

A common variant in the FTO gene region is associated with BMI in the general population and predisposes to adult and childhood obesity
de réir: Lango, H, et al.
Foilsithe / Cruthaithe: (2007)

Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI.
de réir: Freathy, R, et al.
Foilsithe / Cruthaithe: (2008)

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.
de réir: Frayling, T, et al.
Foilsithe / Cruthaithe: (2007)

Genome-wide association data highlight an aetiological role for disturbances in cyclin-dependent kinase pathways in type 2 diabetes
de réir: Timpson, N, et al.
Foilsithe / Cruthaithe: (2007)

Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.
de réir: Lango, H, et al.
Foilsithe / Cruthaithe: (2008)

Genome-wide association (GWA) analysis in 4000 members of a Finnish birth cohort identifies common variants associated with fasting insulin levels and related metabolic traits
de réir: Kaakinen, M, et al.
Foilsithe / Cruthaithe: (2008)

Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: northern Finland 1966 Birth Cohort study.
de réir: Tzoulaki, I, et al.
Foilsithe / Cruthaithe: (2008)

Weight at birth and infancy in relation to adult leukocyte count: a population-based study of 5619 men and women followed from the fetal period to adulthood.
de réir: Canoy, D, et al.
Foilsithe / Cruthaithe: (2009)

A powerful approach to sub-phenotype analysis in population-based genetic association studies.
de réir: Morris, A, et al.
Foilsithe / Cruthaithe: (2010)

Quantitative traits associated with the Type 2 diabetes susceptibility allele in Kir6.2.
de réir: Weedon, M, et al.
Foilsithe / Cruthaithe: (2003)

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
de réir: Zeggini, E, et al.
Foilsithe / Cruthaithe: (2007)

Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach.
de réir: Perry, JR, et al.
Foilsithe / Cruthaithe: (2009)

No association between insulin gene variation and adult metabolic phenotypes in a large Finnish birth cohort.
de réir: Bennett, A, et al.
Foilsithe / Cruthaithe: (2005)

Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population.
de réir: Freathy, R, et al.
Foilsithe / Cruthaithe: (2006)

Variation at the insulin gene VNTR (variable number tandem repeat) polymorphism and early growth: studies in a large Finnish birth cohort.
de réir: Bennett, A, et al.
Foilsithe / Cruthaithe: (2004)

Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects.
de réir: Mitchell, S, et al.
Foilsithe / Cruthaithe: (2003)

Adolescent manifestations of metabolic syndrome among children born to women with gestational diabetes in a general-population birth cohort.
de réir: Vääräsmäki, M, et al.
Foilsithe / Cruthaithe: (2009)

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction
de réir: Weedon, M, et al.
Foilsithe / Cruthaithe: (2006)

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.
de réir: Weedon, M, et al.
Foilsithe / Cruthaithe: (2006)

Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
de réir: Timpson, N, et al.
Foilsithe / Cruthaithe: (2009)

PPARG P12A,Kir6.2/KCNJ11 E23K and early growth in the Northern Finland Birth Cohort of 1966
de réir: Bennett, A, et al.
Foilsithe / Cruthaithe: (2005)

Body size from birth to adulthood as a predictor of self-reported polycystic ovary syndrome symptoms.
de réir: Laitinen, J, et al.
Foilsithe / Cruthaithe: (2003)

The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians
de réir: Freathy, R, et al.
Foilsithe / Cruthaithe: (2006)

Relationship between E23K (an established type II diabetes-susceptibility variant within KCNJ11), polycystic ovary syndrome and androgen levels.
de réir: Barber, T, et al.
Foilsithe / Cruthaithe: (2007)

Disparate genetic influences on polycystic ovary syndrome (PCOS) and type 2 diabetes revealed by a lack of association between common variants within the TCF7L2 gene and PCOS.
de réir: Barber, T, et al.
Foilsithe / Cruthaithe: (2007)

Using imputation to investigate association of low-frequency variants with adiposity in the 1966 Northern Finnish birth cohort
de réir: O'Connell, J, et al.
Foilsithe / Cruthaithe: (2010)

Studies of genome-wide association data support a genetic overlap between type 2 diabetes and prostate cancer
de réir: Elliott, K, et al.
Foilsithe / Cruthaithe: (2008)

Metabolic cardiovascular disease risk factors in women with self-reported symptoms of oligomenorrhea and/or hirsutism: Northern Finland Birth Cohort 1966 Study.
de réir: Taponen, S, et al.
Foilsithe / Cruthaithe: (2004)

Fecundability and spontaneous abortions in women with self-reported oligo-amenorrhea and/or hirsutism: Northern Finland Birth Cohort 1966 Study.
de réir: Koivunen, R, et al.
Foilsithe / Cruthaithe: (2008)

Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome.
de réir: Barber, T, et al.
Foilsithe / Cruthaithe: (2008)

Prevalence of polycystic ovaries in women with self-reported symptoms of oligomenorrhoea and/or hirsutism: Northern Finland Birth Cohort 1966 Study.
de réir: Taponen, S, et al.
Foilsithe / Cruthaithe: (2004)

Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.
de réir: Rafiq, S, et al.
Foilsithe / Cruthaithe: (2008)

Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.
de réir: Groves, C, et al.
Foilsithe / Cruthaithe: (2006)

Large scale case-control and family-based analyses of TCF7L2 variants in > 6000 UK subjects demonstrates an almost two-fold difference in relative risk between homozygote classes
de réir: Groves, C, et al.
Foilsithe / Cruthaithe: (2006)