TNF inhibitors are produced spontaneously by rheumatoid and osteoarthritic synovial joint cell cultures: evidence of feedback control of TNF action.

TNF inhibitors are produced spontaneously by rheumatoid and osteoarthritic synovial joint cell cultures: evidence of feedback control of TNF action.

We have proposed the hypothesis that tumour necrosis factor alpha (TNF-alpha) has a pivotal role in the pathogenesis of rheumatoid arthritis, based on in vitro observations that in RA synovial joint cell cultures removal of TNF-alpha, inhibited other potentially pathogenic cytokines such as the equa...

Descrizione completa

Dettagli Bibliografici
Autori principali:	Brennan, F, Gibbons, D, Cope, A, Katsikis, P, Maini, R, Feldmann, M
Natura:	Journal article
Lingua:	English
Pubblicazione:	1995

Documenti analoghi

Evaluation of the role of cytokines in autoimmune disease: the importance of TNF alpha in rheumatoid arthritis.
di: Feldmann, M, et al.
Pubblicazione: (1992)

TNF-alpha in rheumatoid arthritis and prospects of anti-TNF therapy.
di: Maini, R, et al.
Pubblicazione: (1993)

TNF alpha as a therapeutic target in rheumatoid arthritis.
di: Feldmann, M, et al.
Pubblicazione: (1994)

Differential regulation of tumour necrosis factor receptors (TNF-R) by IL-4; upregulation of P55 and P75 TNF-R on synovial joint mononuclear cells.
di: Cope, A, et al.
Pubblicazione: (1993)

Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis.
di: Brennan, F, et al.
Pubblicazione: (1989)

SOLUBLE TUMOR-NECROSIS-FACTOR (TNF) RECEPTORS ARE INCREASED IN THE SERA AND SYNOVIAL-FLUIDS OF PATIENTS WITH RHEUMATIC DISEASES
di: Cope, A, et al.
Pubblicazione: (1992)

ANTI TNF THERAPY IN RHEUMATOID ARTHRITIS
di: Feldmann, M, et al.
Pubblicazione: (2011)

INCREASED EXPRESSION OF TUMOR-NECROSIS-FACTOR RECEPTORS ON CELLS ISOLATED FROM RHEUMATOID-ARTHRITIS SYNOVIAL JOINTS
di: Gibbons, D, et al.
Pubblicazione: (1992)

TNFα - A pivotal role in rheumatoid arthritis?
di: Brennan, F, et al.
Pubblicazione: (1992)

TNF alpha--a pivotal role in rheumatoid arthritis?
di: Brennan, F, et al.
Pubblicazione: (1992)

Targeting TNF alpha for the therapy of rheumatoid arthritis.
di: Maini, R, et al.
Pubblicazione: (1994)

The role of TNF alpha and IL-1 in rheumatoid arthritis.
di: Feldmann, M, et al.
Pubblicazione: (2001)

Paradoxical effects of a synthetic metalloproteinase inhibitor that blocks both p55 and p75 TNF receptor shedding and TNF alpha processing in RA synovial membrane cell cultures.
di: Williams, L, et al.
Pubblicazione: (1996)

Enhanced expression of tumor necrosis factor receptor mRNA and protein in mononuclear cells isolated from rheumatoid arthritis synovial joints.
di: Brennan, F, et al.
Pubblicazione: (1992)

TNF alpha is an effective therapeutic target for rheumatoid arthritis.
di: Feldmann, M, et al.
Pubblicazione: (1995)

TNF blockade in rheumatoid arthritis: implications for therapy and pathogenesis.
di: Maini, R, et al.
Pubblicazione: (1997)

TNFα blockade in rheumatoid arthritis: Rationale, clinical outcomes and mechanisms of action
di: Elliott, M, et al.
Pubblicazione: (1995)

TNF alpha blockade in rheumatoid arthritis: rationale, clinical outcomes and mechanisms of action.
di: Elliott, M, et al.
Pubblicazione: (1995)

Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures. Comparison of monoclonal anti TNF-alpha antibody with the interleukin-1 receptor antagonist.
di: Butler, D, et al.
Pubblicazione: (1995)

Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.
di: Sacre, S, et al.
Pubblicazione: (2008)

Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures
di: Sacre, S, et al.
Pubblicazione: (2009)

Cytokine expression and networks in rheumatoid arthritis: rationale for anti-TNF alpha antibody therapy and its mechanism of action.
di: Feldmann, M, et al.
Pubblicazione: (1995)

Nonsteroidal anti-inflammatory drugs increase TNF production in rheumatoid synovial membrane cultures and whole blood.
di: Page, T, et al.
Pubblicazione: (2010)

Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis.
di: Cope, A, et al.
Pubblicazione: (1994)

Insights into the pathogenesis of rheumatoid arthritis from application of anti-TNF therapy.
di: Maini, R, et al.
Pubblicazione: (2000)

Beneficial effects of tumour necrosis factor-alpha (TNF-alpha) blockade in rheumatoid arthritis (RA)
di: Maini, R, et al.
Pubblicazione: (1995)

Selective immunosuppression of tumour necrosis factor-alpha in rheumatoid arthritis.
di: Brennan, F, et al.
Pubblicazione: (1995)

From the laboratory to the clinic: Evaluation of cytokines in rheumatoid arthritis highlights TNF-alpha as a new therapeutic target
di: Feldmann, M, et al.
Pubblicazione: (1994)

Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?
di: Feldmann, M, et al.
Pubblicazione: (2001)

TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases
di: Feldmann, M, et al.
Pubblicazione: (2003)

Nerve Growth Factor Regulation by TNF-α and IL-1β in Synovial Macrophages and Fibroblasts in Osteoarthritic Mice
di: Shotaro Takano, et al.
Pubblicazione: (2016-01-01)

Discovery of TNF-alpha as a therapeutic target in rheumatoid arthritis: preclinical and clinical studies.
di: Feldmann, M, et al.
Pubblicazione: (2002)

Discovery of TNF-α as a therapeutic target in rheumatoid arthritis: Preclinical and clinical studies
di: Feldmann, M, et al.
Pubblicazione: (2002)

Detection of transforming growth factor-beta in rheumatoid arthritis synovial tissue: lack of effect on spontaneous cytokine production in joint cell cultures.
di: Brennan, F, et al.
Pubblicazione: (1990)

Development of anti-TNF therapy for rheumatoid arthritis.
di: Feldmann, M
Pubblicazione: (2002)

Soluble TNF receptor production by activated T lymphocytes: differential effects of acute and chronic exposure to TNF.
di: Cope, A, et al.
Pubblicazione: (1995)

The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis.
di: Feldmann, M, et al.
Pubblicazione: (2004)

Monoclonal anti-TNF alpha antibody as a probe of pathogenesis and therapy of rheumatoid disease.
di: Maini, R, et al.
Pubblicazione: (1995)

TNF as a therapeutic target
di: Bondeson, J, et al.
Pubblicazione: (2000)

Single cell immunoprofile of synovial fluid in rheumatoid arthritis with TNF/JAK inhibitor treatment
di: Xuyang Xia, et al.
Pubblicazione: (2025-03-01)