TNF inhibitors are produced spontaneously by rheumatoid and osteoarthritic synovial joint cell cultures: evidence of feedback control of TNF action.

We have proposed the hypothesis that tumour necrosis factor alpha (TNF-alpha) has a pivotal role in the pathogenesis of rheumatoid arthritis, based on in vitro observations that in RA synovial joint cell cultures removal of TNF-alpha, inhibited other potentially pathogenic cytokines such as the equa...

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Những tác giả chính: Brennan, F, Gibbons, D, Cope, A, Katsikis, P, Maini, R, Feldmann, M
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 1995