Dieting reduces plasma tryptophan and alters brain 5-HT function in women.
A three week low calorie diet significantly reduced both total plasma tryptophan and the ratio of tryptophan to competing amino acids in a group of 15 healthy volunteers. Despite a similar percentage weight loss the reduction in plasma tryptophan was greater in women than men. In addition, only in w...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
1990
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| _version_ | 1826280838926434304 |
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| author | Anderson, I Parry-Billings, M Newsholme, E Fairburn, C Cowen, P |
| author_facet | Anderson, I Parry-Billings, M Newsholme, E Fairburn, C Cowen, P |
| author_sort | Anderson, I |
| collection | OXFORD |
| description | A three week low calorie diet significantly reduced both total plasma tryptophan and the ratio of tryptophan to competing amino acids in a group of 15 healthy volunteers. Despite a similar percentage weight loss the reduction in plasma tryptophan was greater in women than men. In addition, only in women was dieting associated with increased prolactin secretion following intravenous tryptophan, a measure of brain 5-hydroxytryptamine (5-HT) function. These results suggest that dieting reduces the availability of circulating tryptophan for brain 5-HT synthesis. Women appear more vulnerable than men both to this effect and to its consequences for brain 5-HT function. Altered brain 5-HT function may play a part in some of the psychological consequences of dieting, including the development of clinical eating disorders. |
| first_indexed | 2024-03-07T00:19:45Z |
| format | Journal article |
| id | oxford-uuid:7c20ff94-63e2-4ee6-8fd7-0de8902c7e4d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T00:19:45Z |
| publishDate | 1990 |
| record_format | dspace |
| spelling | oxford-uuid:7c20ff94-63e2-4ee6-8fd7-0de8902c7e4d2022-03-26T20:55:00ZDieting reduces plasma tryptophan and alters brain 5-HT function in women.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:7c20ff94-63e2-4ee6-8fd7-0de8902c7e4dEnglishSymplectic Elements at Oxford1990Anderson, IParry-Billings, MNewsholme, EFairburn, CCowen, PA three week low calorie diet significantly reduced both total plasma tryptophan and the ratio of tryptophan to competing amino acids in a group of 15 healthy volunteers. Despite a similar percentage weight loss the reduction in plasma tryptophan was greater in women than men. In addition, only in women was dieting associated with increased prolactin secretion following intravenous tryptophan, a measure of brain 5-hydroxytryptamine (5-HT) function. These results suggest that dieting reduces the availability of circulating tryptophan for brain 5-HT synthesis. Women appear more vulnerable than men both to this effect and to its consequences for brain 5-HT function. Altered brain 5-HT function may play a part in some of the psychological consequences of dieting, including the development of clinical eating disorders. |
| spellingShingle | Anderson, I Parry-Billings, M Newsholme, E Fairburn, C Cowen, P Dieting reduces plasma tryptophan and alters brain 5-HT function in women. |
| title | Dieting reduces plasma tryptophan and alters brain 5-HT function in women. |
| title_full | Dieting reduces plasma tryptophan and alters brain 5-HT function in women. |
| title_fullStr | Dieting reduces plasma tryptophan and alters brain 5-HT function in women. |
| title_full_unstemmed | Dieting reduces plasma tryptophan and alters brain 5-HT function in women. |
| title_short | Dieting reduces plasma tryptophan and alters brain 5-HT function in women. |
| title_sort | dieting reduces plasma tryptophan and alters brain 5 ht function in women |
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