Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification

Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification

Stromal-derived intratumoural heterogeneity (ITH) has been shown to undermine molecular stratification of patients into appropriate prognostic/predictive subgroups. Here, using several clinically relevant colorectal cancer (CRC) gene expression signatures, we assessed the susceptibility of these sig...

Полное описание

Библиографические подробности
Главные авторы:	Dunne, P, Alderdice, M, O'Reilly, P, Roddy, A, McCorry, A, Richman, S, Maughan, T, McDade, S, Johnston, P, Longley, D, Kay, E, McArt, D, Lawler, M
Формат:	Journal article
Язык:	English
Опубликовано:	Springer Nature 2017

Схожие документы

Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification
по: Philip D. Dunne, и др.
Опубликовано: (2017-05-01)

Prospective patient stratification into robust cancer-cell intrinsic subtypes from colorectal cancer biopsies
по: Alderdice, M, и др.
Опубликовано: (2018)

Standardising RNA profiling based biomarker application in cancer—The need for robust control of technical variables
по: Stewart, J, и др.
Опубликовано: (2017)

Ontogeny of intestinal intratumoural macrophages and their contribution in cancer regulation
по: Soncin, Irene
Опубликовано: (2018)

Endoscopic Ultrasound-Guided Intratumoural Therapy for Pancreatic Cancer
по: Brian M Yan, и др.
Опубликовано: (2008-01-01)

“Thus, I Give Up the Spear!”: Sovereignty and Violence against Animals
по: Seán McCorry
Опубликовано: (2016-03-01)

A Bestiary in Five Fingers
по: Seán McCorry
Опубликовано: (2014-11-01)

classifieR a flexible interactive cloud-application for functional annotation of cancer transcriptomes
по: Gerard P. Quinn, и др.
Опубликовано: (2022-03-01)

Intratumoural production of TNFα by bacteria mediates cancer therapy.
по: Carola Murphy, и др.
Опубликовано: (2017-01-01)

Intratumoural microbiota: a new frontier in cancer development and therapy
по: Yaqi Cao, и др.
Опубликовано: (2024-01-01)

Bronchoscopic intratumoural therapies for non-small cell lung cancer
по: Andrew DeMaio, и др.
Опубликовано: (2020-06-01)

Connecting microsoft exchange server /
по: McCorry, Kieran, 1968-
Опубликовано: (1999)

Absence of lymphangiogenesis and intratumoural lymph vessels in human metastatic breast cancer.
по: Williams, C, и др.
Опубликовано: (2003)

Role of intratumoural heterogeneity in cancer drug resistance: molecular and clinical perspectives
по: Nicholas A. Saunders, и др.
Опубликовано: (2012-06-01)

Identification of candidate small-molecule therapeutics to cancer by gene-signature perturbation in connectivity mapping.
по: Darragh G McArt, и др.
Опубликовано: (2011-01-01)

Overcoming intratumoural heterogeneity for reproducible molecular risk stratification: a case study in advanced kidney cancer
по: Alexander L. R. Lubbock, и др.
Опубликовано: (2017-06-01)

Essentials of human physiology for pharmacy /
по: 188291 McCorry, Laurie Kelly
Опубликовано: (2009)

Symptomatic Schizophrenia with Moya Moya Disease
по: Gerard McDade
Опубликовано: (1991-01-01)

The Public Library in the Community: Governance and Funding
по: Barbara McDade
Опубликовано: (2013-03-01)

The ratio of intratumour to stromal infiltrating lymphocytes better predicts prognosis in breast cancer
по: Baoyi Zhang, и др.
Опубликовано: (2023-05-01)

Study on the Value of DCE-MRI in Differentiating Glossitis and Tongue Cancer and the Intratumour Heterogeneity
по: Liu F, и др.
Опубликовано: (2021-09-01)

Gastrointestinal Stromal Tumour with Intratumoural Endometriosis
по: Md Ali Osama, и др.
Опубликовано: (2021-12-01)

Improving Cancer Gene Expression Data Quality through a TCGA Data-Driven Evaluation of Identifier Filtering
по: Kevin K. McDade, и др.
Опубликовано: (2015-12-01)

Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer
по: Katharina von Loga, и др.
Опубликовано: (2020-01-01)

Intratumour heterogeneity in microRNAs expression regulates glioblastoma metabolism
по: Huda Alfardus, и др.
Опубликовано: (2021-08-01)

surviveR: a flexible shiny application for patient survival analysis
по: Tamas Sessler, и др.
Опубликовано: (2023-12-01)

Self-organization and regulation of intrinsically disordered proteins with folded N-termini
по: Simister, P, и др.
Опубликовано: (2011)

An investigation of adjustable microgravity workstation anthropometrics through analyses of neutral body posture and lower leg muscular fatigue characteristics
по: McDade, Theodore Pashley
Опубликовано: (2008)

Legionella and the Prevention of Legionellosis
по: Joseph E. McDade
Опубликовано: (2008-06-01)

Segue: Brief summaries of articles on pertinent emerging issues published elsewhere.
по: Joseph E. McDade
Опубликовано: (2004-05-01)

The Microbial Challenge: Human-Microbe Interactions
по: Joseph E. McDade
Опубликовано: (2002-12-01)

Addressing the Potential Threat of Bioterrorism—Value Added to an Improved Public Health Infrastructure
по: Joseph E. McDade
Опубликовано: (1999-08-01)

Segue: Brief summaries of articles on pertinent emerging issues published elsewhere.
по: Joseph E. McDade
Опубликовано: (2004-06-01)

Biodistribution and nuclear import of 111In-labeled HIV-1 tat peptide immunoconjugates after intravenous or intratumoural injection in tumour-bearing mice
по: Cornelissen, B, и др.
Опубликовано: (2006)

Feasibility of CT quantification of intratumoural 166Ho-microspheres
по: R. C. Bakker, и др.
Опубликовано: (2020-05-01)

Intratumoural microbiota: from theory to clinical application
по: Hao Ji, и др.
Опубликовано: (2023-06-01)

Don’t be fooled by the fat: A rare case of renal cell carcinoma with intratumoural fat
по: Hannah Morris, и др.
Опубликовано: (2020-05-01)

Don’t be fooled by the fat: A rare case of renal cell carcinoma with intratumoural fat
по: Hannah Morris, и др.
Опубликовано: (2020-05-01)

Experimental determination of near-solidus peridotite trace partition coefficients
по: McDade, P, и др.
Опубликовано: (2002)

Trace element partitioning on the Tinaquillo Lherzolite solidus at 1.5 GPa
по: McDade, P, и др.
Опубликовано: (2003)